Models, mechanisms and clinical evidence for cancer dormancy

By J. Aguirre-Ghiso. Nature Reviews. Cancer, 2007

1,645 citations recorded by the source corpus.

Subfields: Cancer Research, Cell Biology

View Paper: https://www.semanticscholar.org/paper/adac5b0ca3d8e431636ff395b560b99bd7df99cd

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cancer Research

1. J. Pollard
2. J. Joyce
3. Mina J. Bissell
4. Hans Clevers
5. E. Wagner
6. D. Stainier
7. A. Nebreda
8. D. Lyden

In Cell Biology

1. H. Peinado
2. J. Joyce
3. J. Pollard
4. Hans Clevers
5. E. Wagner
6. D. Stainier
7. A. Nebreda
8. D. Lyden

Citations in the corpus

• Hallmarks of cancer: the next generation. (2011, neutral): “Other mechanisms of micrometastatic dormancy may involve anti-growth signals embedded in normal tissue extracellular matrix (Barkan et al., 2010) and tumor-sup-pressing actions of the immune system (Teng et al., 2008; Aguirre-Ghiso, 2007).”
• EMERGING BIOLOGICAL PRINCIPLES OF METASTASIS (2017, neutral): “Dormancy Programs The latent, clinically inapparent phase of metastasis might well be the result of factors beyond those cited here that render carcinoma cells unable to proliferate, such as an inability to induce angiogenesis or active suppression by the immune system (Aguirre-Ghiso, 2007).”
• Tuning gene expression to changing environments: from rapid responses to evolutionary adaptation (2008, background): “Moreover, cancer cells sustain rapid proliferation by upregulating ribosome- and other growth-related genes, but can also enter dormant stages with increased resistance to drug”
• The perivascular niche regulates breast tumor dormancy (2013, background): “(a) Heat map of ECM proteins (spectral counts) from (1) neovascular tiphigh cultures (LF+ctrl shRNA EC) normalized by lung stroma (LF), (2) neovascular tiplow cultures (LF+Notch1 shRNA EC) normalized by lung stroma (LF) and (3) tiphigh cultures normalized by tiplow cultures (sorted high to low with ”
• Signal integration by JNK and p38 MAPK pathways in cancer development (2009, background): “Several studies have also described pro-survival roles for p38α, which can be mediated by the induction of cell differentiation or by anti-apoptotic inflammatory signals, such as the cytokine interleukin-6 (IL-6), as well as by a quiescent state known as cancer dormancy that may be important for can”
• Microenvironmental regulation of metastasis (2009, background): “In another phenomenon, termed angiogenic dormancy, there is a balance of proliferation and apoptosis that results in micrometastases that do not progress furthe”
• Hematopoietic stem cells reversibly switch from dormancy to self-renewal during homeostasis and repair. (2009, neutral): “It is thought that some leukemic stem cells such as chronic myeloid leukemia (CML) stem cells are also in a state of quiescence/dormancy, which is a possible mechanism for their resistance to antiproliferative chemotherapy ( Aguirre-Ghiso, 2007; Trumpp and Wiestler, 2008).”
• The cancer stem cell: premises, promises and challenges (2011, background): “Metastatic relapse in breast cancer, for instance, can occur more than a decade after initial treatmen”