Human TLR7 or TLR8 independently confer responsiveness to the antiviral compound R-848

By M. Jurk, F. Heil, J. Vollmer, C. Schetter, A. Krieg, H. Wagner, G. Lipford, S. Bauer. Nature Immunology, 2002

1,102 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/15f8a522ec5a491bd010d4905da2e73ce82f7a59

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Epidemiology

In Immunology

Citations in the corpus

Pattern Recognition Receptors and the Innate Immune Response to Viral Infection (2011, background): “Human TLR7 and TLR8 were first shown to respond to the imidazoquinoline-like compound resiquimod (R-848), a synthetic drug recognized for its antiviral and antitumor activity [36,37].”
Selected Toll-like receptor agonist combinations synergistically trigger a T helper type 1–polarizing program in dendritic cells (2005, background): “We thank G. Natoli and A. Macagno for critical reading and A. Martı́nFontecha for help with the experiments using mouse DCs. Supported in part by the Swiss National Science Foundation (31-63885), National Institutes of Health (U19AI057266/01) and European Community (Sixth Framework Programme, contra”
Synthetic TLR Agonists Reveal Functional Differences between Human TLR7 and TLR8 (2005, neutral): “The role of TLR8 is not well established due to the apparent lack of function of murine TLR8 and the lack of TLR8selective agonists (23).”
The Interleukin-1 Receptor/Toll-Like Receptor Superfamily: Signal Transduction During Inflammation and Host Defense (2000, background): “TLR-8 has also been identif ied as a receptor for imiquimod (115).”
NF-κB and the immune response (2006, background): “…initially found to recognize synthetic antiviral compounds, namely imidazoquinolines, the azoquinoline R-848 and loxoribine (Hemmi et al., 2002; Jurk et al., 2002), TLR7 and human TLR8 are now known to recognize guanosine- or uridine-rich singlestranded RNA derived from RNA viruses (Diebold et…”
Recognition of microbial infection by Toll-like receptors. (2003, background): “Jurk M, Heil F, Vollmer J, Schetter C, Krieg AM, Wagner H, Lipford G, Bauer S: Human TLR7 or TLR8 independently confer responsiveness to the antiviral compound R-848.”
Interferons and viruses: an interplay between induction, signalling, antiviral responses and virus countermeasures. (2008, background): “The ligands for TLR7 include immunomodulatory compounds such as imiquimod and R848 (Hemmi et al., 2002; Jurk et al., 2002; Heil et al., 2003) and single-stranded RNA (ssRNA) molecules, either synthetic (Diebold et al.”
Toll-like receptors in antiviral innate immunity (2013, background): “However, because both TLR7 and TLR8 respond to single-stranded viral nucleic acids, they are commonly linked together; however, there are functional differences between the two [106,107].”
Toll-like receptors in innate immunity. (2004, neutral): “Human TLR7 and TLR8, but not murine TLR8, recognizes imid-azoquinoline compounds (27).”