Nuclear Cloning and Epigenetic Reprogramming of the Genome

By W. Rideout, K. Eggan, R. Jaenisch. Science, 2001

686 citations recorded by the source corpus.

Subfields: Genetics, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/128ebf299718ccee5f3d8629d854370fe688e950

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Genetics

1. Wolf Reik
2. E. Li
3. A. Bird
4. W. Dean
5. Jörn Walter
6. R. Jaenisch
7. Manel Esteller
8. Fátima Santos

In Molecular Biology

1. Wolf Reik
2. A. Bird
3. E. Li
4. R. Jaenisch
5. Yi Zhang
6. K. Hochedlinger
7. W. Dean
8. S. Yamanaka

Citations in the corpus

• Nuclear reprogramming to a pluripotent state by three approaches (2010, background): “In addition, cell 'rejuvenation' is evident from the lengthening of telomeres and the increased activity of telomeras”
• Dynamic reprogramming of DNA methylation in the early mouse embryo. (2002, background): “Whether the consistently low efficiency of somatic nuclear cloning is related to the inability of a somatic nucleus to undergo the normal changes in methylation is an attractive question to pose (Reik et al., 2001; Rideout et al., 2001).”
• Epigenetic modifications and human disease (2010, background): “In multicellular organisms, the ability of epigenetic marks to persist during development and potentially be transmitted to offspring may be necessary for generating the large range of different phenotypes that arise from the same genotyp”
• Embryonic stem cells: prospects for developmental biology and cell therapy. (2005, background): “The fact that the vast majority of cloned embryos die during embryonic development, despite their normal chromosome complement, also suggests that epigenetic reprogramming in reconstructed oocytes is incomplete (297).”
• Resistance of IAPs to methylation reprogramming may provide a mechanism for epigenetic inheritance in the mouse (2003, methodology): “Epigenetic modifications such as DNA methylation have important roles in genome function and stability (Bird, 2002; Ben-Porath and Cedar, 2001; Rideout et al., 2001; Bestor, 2000; Reik et al., 2001; Surani, 2001).”
• Epigenetics as a unifying principle in the aetiology of complex traits and diseases (2010, background): “These epigenetic differences are vestiges of the different epigenetic signatures in two zygotes: one highly artificial, and the other natura”
• Chromatin modification and epigenetic reprogramming in mammalian development (2002, background): “Aberrant expression of imprinted genes and of Oct4 might contribute to the placental defects that frequently occur in cloned animal”
• Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals (2003, background): “Few embryos survive to birth, and many of the survivors die in the postnatal period or succumb prematurely to a variety of abnormalitie”
• Correction of a genetic defect by nuclear transplantation and combined cell and gene therapy. (2002, positive): “The development of somatic cell nuclear transfer (NT) techniques to produce viable cloned mammals (Wakayama et al., 1998; Wilmut et al., 1997) demonstrated the ability of oocyte cytoplasm to reprogram a somatic donor nucleus to a pluripotent state ( Rideout et al., 2001 ).”