Epigenetics as a unifying principle in the aetiology of complex traits and diseases

By Art Petronis. Nature, 2010

718 citations recorded by the source corpus.

Subfields: Genetics, Molecular Biology, Pediatrics, Perinatology and Child Health

View Paper: https://www.semanticscholar.org/paper/c7df1c6aed5d7f9aed5e9239da72b8bb0ff3eb2b

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In Genetics

In Molecular Biology

In Pediatrics, Perinatology and Child Health

Citations in the corpus

Genetics of bipolar disorder. (2011, background): “Epigenetic variation, which includes several kinds of inherited variation not reflected in the DNA sequence, such as histone modifications, may prove to be quite important (Petronis 2010).”
Functional annotation of the human brain methylome identifies tissue-specific epigenetic variation across brain and blood (2012, background): “Because aberrant DNA methylation is being increasingly implicated in the etiology of complex disease phenotypes, including several mental health disorders [44], a key Davies et al.”
A beta-mixture quantile normalization method for correcting probe design bias in Illumina Infinium 450 k DNA methylation data (2012, background): “In the past few years, the field of epigenomics has risen to prominence (Feinberg, 2010; Petronis, 2010).”
Candidate Genes and Political Behavior (2012, background): “BROADER ISSUES IN GENETICS According to many top researchers in the field, the science of genetics is undergoing a paradigm shift (Dear 2009; Gressler and Haslberger 2010; McClellan and King 2010; Ooi and Wood 2008; Petronis 2010; Sgaramella and Astolfi 2010; Whitelaw and Whitelaw 2006).”
What Do We Know About Short and Long Term Effects of Early Life Exposure to Pollution (2014, neutral): “In particular, pollutionmayhave epigenetic effects—permanent alterations in gene expression—that can negatively impact intellectual growth and maturity later in life (Petronis 2010).”
Inequality at Birth: Some Causes and Consequences (2011, neutral): “Arturas Petronis (2010) argues that “it is difficult to visualize how highly stable DNA sequences can account for heritability which is malleable and context-dependent” (p. 722).”
Beyond GWASs: illuminating the dark road from association to function. (2013, background): “Epigenetic changes such as DNA methylation and histone modifications are required for normal gene regulation and are therefore obvious candidate targets for GWAS associations.(91) DNA methylation is perhaps the most extensively studied epigenetic modification.”
Epigenome-Wide Association Studies for common human diseases (2011, background): “However, there is now increasing interest in exploring how non-genetic variation, including epigenetic factors, could influence complex disease aetiolog”
Killing Me Softly: The Fetal Origins Hypothesis (2011, background): “The period while the fetus is in utero may be particularly important for setting these switches [Petronis, 2010].”