Correction of a genetic defect by nuclear transplantation and combined cell and gene therapy.

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How researchers see this paper

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Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals (2003, background): “Indeed, it has been shown in a 'proof of principle' experiment that nuclear cloning combined with gene therapy can partially restore the immune defect in Rag2 mutant mic”
Sequential expression of pluripotency markers during direct reprogramming of mouse somatic cells. (2008, background): “The generation of pluripotent cell lines from somatic cells has great potential for basic research as well as clinical applications (Hochedlinger and Jaenisch, 2003; Rideout et al., 2002).”
Disease-specific induced pluripotent stem (iPS) cells (2008, neutral): “In a proof of principle experiment, NT-embryonic stem (ES) cells generated from mice with genetic immunodeficiency were used to combine gene and cell therapy to repair the genetic defect (Rideout et al., 2002).”
Homologous recombination in human embryonic stem cells (2003, neutral): “Homologous recombination in human ES cells might also be used for recently described approaches combining therapeutic cloning with gene therap”
Embryonic stem cells: prospects for developmental biology and cell therapy. (2005, background): “A demonstration of this potential was published in 2002 (298).”