Epigenetic modifications and human disease

By Anna Portela, Manel Esteller. Nature Biotechnology, 2010

2,757 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/38788e268020935fecab1603bb130d51b02ffd26

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Biology

Citations in the corpus

The Human Sciences in a Biological Age (2013, background): “For an excellent review of work on epigenetics and human disease, see Portela and Esteller (2010).”
Ensemble deep learning in bioinformatics (2020, background): “Additional layers of genetic information including structural variants 56 (for example, copy number variations (CNVs)) and epigenetic modifications 57 of the genome bring important insight to the understanding of biological systems, populations and complex diseases.”
Epigenetic protein families: a new frontier for drug discovery (2012, neutral): “BT1(1) SFM BT2(1) L3M BTL(1) L3MBTL3(1) L3MBTL4(1) L3MBTL4(3) SFMBT1(4) SFM BT2( 4) L3M BTL( 3) L3 MB TL 3(3 ) L3 MB TL 2(4 ) M BT D 1( 4) L3 M BT L( 2) L3M BTL4(2) L3M BTL3(2) SC M H 1(2) SCM L2(2) L3MBTL2(3) MBTD1(3) SFMBT1(3) SFMBT 2(3) MBTs 390 | MAY 2012 | VOLUME 11 www.nature.com/reviews/drugd”
Mechanisms of diabetic complications. (2013, background): “Recently, these posttranslational modifications, such as DNA and histone methylation, have been suggested as contributors to diabetic complications (119, 489) since they regulate many cellular processes including proliferation, differentiation, and apoptosis in disease states such as cancer (470, 53”
Histone lactylation drives oncogenesis by facilitating m6A reader protein YTHDF2 expression in ocular melanoma (2021, background): “The dysregulation of histone modifications can shift the balance of transcription activation and repression, thus resulting in disease occurrence and progression [6].”
Mapping and elucidating the function of modified bases in DNA (2017, background): “In addition, certain genes are hypermethylated in a number of neurodegenerative disorders, including Alzheimer’s disease.(103)”
RB1 methylation by SMYD2 enhances cell cycle progression through an increase of RB1 phosphorylation. (2012, background): “Other groups have also proposed involvement of HMTs in malignant alterations of human cells [37–39].”