Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals

By R. Jaenisch, A. Bird. Nature Genetics, 2003

6,249 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/c68001e5f2923ab5f1012ef5ae20523a67be422f

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Citations in the corpus

PGC7/Stella protects against DNA demethylation in early embryogenesis (2007, neutral): “dtd" [ ]> DNA methylation is an important means of epigenetic gene regulatio”
DNA Demethylation Dynamics (2011, background): “…gene silencing that leads to genomic imprinting, X chromosome inactivation, suppression of transposable elements, and the establishment and maintenance of stable cellular identities (Bird, 2002; De Carvalho et al., 2010; Deaton and Bird, 2011; Goll and Bestor, 2005; Jaenisch and Bird, 2003).”
Ten Putative Contributors to the Obesity Epidemic (2009, positive): “Epigenetics describes the study of mitotically heritable alterations in gene expression potential that are not caused by changes in DNA sequence (Jaenisch and Bird, 2003).”
The multiple-hit pathogenesis of non-alcoholic fatty liver disease (NAFLD). (2016, background): “NASH and is mostly influenced by dietary deficiency of fundamental methyl donors such as betaine, choline and folate [103].”
Hydroxylation of 5-methylcytosine by TET1 promotes active DNA demethylation in the adult brain (2011, neutral): “5mCs, especially when clustered, are important transcriptional silencers at gene promoters and endogenous retrotransposons in the genome (Jaenisch and Bird, 2003).”
Mechanisms and functions of Tet protein-mediated 5-methylcytosine oxidation. (2011, background): “During development, stem and progenitor cells differentiate into functionally diverse cell types with unique gene expression profiles, which are regulated, at least in part, by cell type-specific covalent modifications of DNA and histones (Jaenisch and Bird 2003).”
Epigenetic reprogramming and induced pluripotency (2009, background): “Upon fertilization, the paternal genome becomes actively demethylated in the zygote, while the maternal genome looses its methylation marks passively during cleavage divisions (Jaenisch and Bird, 2003).”
Inherited epigenetic variation — revisiting soft inheritance (2006, background): “When present, 5mC serves as a guide for the placement and maintenance of other epigenetic codes, such as the repertoire of post-translational modifications of the core histone proteins that package DNA into nucleosomal particle”