Chemokines, sphingosine-1-phosphate, and cell migration in secondary lymphoid organs.

By J. Cyster. Annual Review of Immunology, 2005

953 citations recorded by the source corpus.

Subfields: Immunology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/0fed8f0436d41094102e51fa376c95db3c1a2399

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Citations in the corpus

Fibroblastic reticular cells in lymph nodes regulate the homeostasis of naive T cells (2007, background): “SLOs are the sites where primary immune responses are initiate”
“Inside-Out” Signaling of Sphingosine-1-Phosphate: Therapeutic Targets (2008, background): “…of the S1P1 receptor that results in prolonged receptor downregulation (Matloubian et al., 2004), thereby depriving thymocytes and lymphocytes of an S1P signal necessary for their egress from secondary lymphoid tissues (Gräler and Goetzl, 2004; Matloubian et al., 2004; Cyster, 2005) (Fig.”
Follicular shuttling of marginal zone B cells facilitates antigen transport (2008, background): “FDCs are also a source of B lymphocyte chemoattractant (BLC; also called CXCL13), a chemokine that attracts B cells to follicles by engaging the receptor CXCR5 (ref”
Immunosurveillance by hematopoietic progenitor cells trafficking through blood, lymph, and peripheral tissues. (2007, background): “S1P plays a key role in enabling lymphocyte egress from the thymus into the blood and from SLOs into the lymph (Cyster, 2005; Massberg and von Andrian, 2006; Rosen and Goetzl, 2005).”
Lipid signalling in disease (2008, background): “; when phosphorylated by lipid kinases, however, sphingosine is converted into sphingosine-1-phosphate (S1P), which promotes cell growth and proliferation by a still poorly understood intracellular action as well as by extracellular signalling through a set of different G protein-coupled receptors ”
Chemokines and chemokine receptors: positioning cells for host defense and immunity. (2014, background): “Together, this promotes further influx of CCR7-positive cells, thereby promoting cellular interactions (24).”
Immune cell migration in inflammation: present and future therapeutic targets (2005, methodology): “Pharmacological inhibition of this pathway with drugs such as FTY720 traps T cells in lymph nodes and primary organs, leading to peripheral T cell depletio”
Finding a way out: lymphocyte egress from lymphoid organs (2007, background): “S1P 1 and lymphocyte egress The entry of lymphocyte into lymphoid organs involves the expression of a combinatorial array of selectins, chemokine receptors and integrins, but only one requirement for egress has been identified so fa”
The who, how and where of antigen presentation to B cells (2009, background): “It is now widely understood that beneath the protective outer collagenous capsule, a lymph node is divided into three discrete (but non-rigid) regions that are defined by the expression of specific chemokine”
Mammalian G proteins and their cell type specific functions. (2005, background): “Known lymphocyte chemoattractants either belong to the large family of chemokines (355, 500) or to the lysophospholipid family, like sphingosine-1-phosphate (S1P) or lysophosphatidic acid (LPA) (123, 221, 282).”