Fibroblastic reticular cells in lymph nodes regulate the homeostasis of naive T cells

By A. Link, T. Vogt, S. Favre, M. Britschgi, H. Acha-Orbea, B. Hinz, J. Cyster, S. Luther. Nature Immunology, 2007

995 citations recorded by the source corpus.

Subfields: Immunology

View Paper: https://www.semanticscholar.org/paper/dfdb7299e347df00e0115ef10593b0c4ebc3b8c5

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In Immunology

1. A. Luster
2. J. Girard
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4. S. Kaech
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Citations in the corpus

• Orchestrating the orchestrators: chemokines in control of T cell traffic (2008, background): “CCL19 and CCL21 are encoded by two closely linked gene clusters and are expressed differently by different lymph node cell”
• New insights into the regulation of T cells by γc family cytokines (2009, neutral): “In contrast to other γ c family cytokines, the levels of which increase after immune cell activation, IL-7 is constitutively produced by stromal and epithelial cells in the bone marrow and thymus and by fibroblastic reticular cells in the T cell zones of secondary lymphoid organ”
• Blimp-1 promotes terminal differentiation of virus-specific CD8 T cells and represses the acquisition of central memory T cell properties (2009, background): “Finally, higher expression of lymph node homing receptors CD62L and CCR7 and retention in lymphoid organs may also contribute to the increased survival of the Prdm1 / cells by increasing their exposure to prosurvival cytokines at these sites (Link et al., 2007).”
• CCR7 and its ligands: balancing immunity and tolerance (2008, background): “In non-inflamed lymph nodes, fibroblastic reticular cells seem to be the only source of CCL19 production in both humans and mic”
• The IL-1-Like Cytokine IL-33 Is Constitutively Expressed in the Nucleus of Endothelial Cells and Epithelial Cells In Vivo: A Novel ‘Alarmin’? (2008, background): “FRCs play critical roles in lymph node organization and function by modulating lymphocyte survival and migration within T-cell areas [25,37].”