The superoxide-generating NADPH oxidase: structural aspects and activation mechanism

By P. Vignais. Cellular and Molecular Life Sciences (CMLS), 2002

812 citations recorded by the source corpus.

Subfields: Immunology, Neurology, Physiology

View Paper: https://www.semanticscholar.org/paper/0f80b8c804722c7ea8bef481654c7ba9f267e1e1

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

1. Rhian M. Touyz
2. E. Schiffrin
3. J. Lambeth
4. B. Lassègue
5. R. Clempus
6. J. Fiedor
7. Xia Zhang
8. Wei-Wei Chen

In Neurology

1. E. Schiffrin
2. Rhian M. Touyz
3. J. Fiedor
4. Xia Zhang
5. Wei-Wei Chen
6. A. Segal
7. Wenjuan Huang
8. M. Valko

In Physiology

1. Rhian M. Touyz
2. E. Schiffrin
3. J. Lambeth
4. R. Clempus
5. B. Lassègue
6. J. Fiedor
7. Xia Zhang
8. Wei-Wei Chen

Citations in the corpus

• Oxidative stress is inherent in prostate cancer cells and is required for aggressive phenotype. (2008, background): “In addition to mitochondria, ROS generated through extramitochondrial NAD(P)H oxidase (Nox) system/s (4, 5) are also”
• Nox enzymes, ROS, and chronic disease: an example of antagonistic pleiotropy. (2007, background): “These cells express very large amounts of gp91phox, now also called Nox2, along with its regulatory subunits p47phox, p67phox, p40phox and Rac2, reviewed in [1,2].”
• The Role of Selenium in Inflammation and Immunity: From Molecular Mechanisms to Therapeutic Opportunities (2012, background): “The main nonmitochondrial sources of ROS are the NADPH oxidases (NOX, also called phagocytic oxidases, PHOX), which are multicomponent enzymes consisting of cytosolic and membrane-bound proteins (257).”
• Role of oxidative stress in Alzheimer's disease (2016, background): “Thus, the major enzymatic sources of O2• ̄ are NADPH oxidases located in various cell membranes, including polymorphonuclear, macrophages and endothelial cells (32-34), as well as cytochrome P450• ̄ and H2O2-dependent oxygenases (35,36).”
• How neutrophils kill microbes. (2005, background): “Detailed reviews of the biochemistry and bioenergetics of this system have recently been undertaken (12, 13), to which I refer readers.”
• Role of oxygen radicals in DNA damage and cancer incidence (2004, background): “When NAD(P)H oxidase is activated, it takes NAD(P)H from the cytoplasm and passes electrons to O2-producing superoxide within the plasma membrane or on its outer surface [30, 31]”
• Reactive oxygen species in vascular biology: implications in hypertension (2004, positive): “Phagocytic NAD(P)H oxidase comprises at least five components: (phox for PHagocyte OXidase), p47phox, p67phox, p40phox, p22phox, and gp91phox (Babior et al. 2002; Vignais 2002).”
• Vascular NAD(P)H oxidases: specific features, expression, and regulation. (2003, background): “Because it is closely related to the vascular enzymes, we will first briefly describe the main features of the well-characterized neutrophil NADPH oxidase, which have been reviewed previously (6, 8, 33, 41, 110, 111, 206).”
• Chemical Basis of Reactive Oxygen Species Reactivity and Involvement in Neurodegenerative Diseases (2019, background): “NADPH oxidase catalyzes the monoelectronic reduction of molecular oxygen, thus producing O2•‒ [8,9] that is released either outside the cell (for phagocytic cells) or inside the cell (for non-phagocytic cells) [10].”
• Potential Role of Carotenoids as Antioxidants in Human Health and Disease (2014, background): “The superoxide radical may also be generated enzymatically by respective NADPH oxidases [39,44,45] or the xanthine oxidase system.”
• Hydrogen Peroxide: A Signaling Messenger (2006, neutral): “In general, in mammalian cells, ROS production is greater in proliferating subconfluent cultures compared with confluent cells (23, 75, 158).”
• ROS stress in cancer cells and therapeutic implications. (2004, background): “In addition, ROS can also be produced by a family of membrane-bound enzymes such as NAD(P)H oxidases, which seem to affect cell proliferation and apoptosis (Wientjes and Segal, 1995; Vignais, 2002; Brar et al., 2003).”