Oxidative stress is inherent in prostate cancer cells and is required for aggressive phenotype.

By B. Kumar, S. Koul, L. Khandrika, R. Meacham, H. Koul. Cancer Research, 2008

734 citations recorded by the source corpus.

Subfields: Immunology, Molecular Biology, Physiology

View Paper: https://www.semanticscholar.org/paper/be0f0e395a7915b470003fc4a4ec2b0214d5b9d2

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

1. P. Storz
2. G. Barrera

In Molecular Biology

1. G. Barrera
2. Geou-Yarh Liou
3. D. Trachootham
4. Peng Huang
5. J. Alexandre
6. P. Storz
7. L. Kamendulis
8. J. Klaunig

In Physiology

1. P. Storz
2. G. Barrera

Citations in the corpus

• Free Radicals: Properties, Sources, Targets, and Their Implication in Various Diseases (2014, background): “2008 [142] have reported elevated ROS levels in prostate cancer cells compared with normal cells.”
• Oxidative Stress and Lipid Peroxidation Products in Cancer Progression and Therapy (2012, background): “The increase in 8OHdG has been demonstrated in thyroid neoplasia [26], in squamous cell carcinoma [27], in nonsmall-cell lung cancer [28], and in prostate cancer cells [29].”
• Reactive oxygen species in cancer (2010, background): “While a role for ROS-activated Erk1/2 signaling in cell proliferation is well established [61, 65, 67], its ability to regulate cancer cell survival seems to be cell type specific [64, 68, 69].”
• Oxidative Stress and Oxidative Damage in Carcinogenesis (2010, background): “Recent studies have shown an important role for reactive oxygen species in tumor development (Kumar et al. 2008; Ishikawa et al. 2008).”
• Oxidative Stress in Aging Human Skin (2015, background): “8-oxo-2'deoxyguanosine are found in a multitude of cancers [298,300–304].”
• Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach? (2009, background): “In solid tumours, studies have shown increased levels of oxidative damage products, such as oxidized DNA base (8OHdG), and lipid peroxidation products in clinical tumour specimens, plasma and cancer cell line”
• Oxidative stress and metabolic disorders: Pathogenesis and therapeutic strategies. (2016, background): “This uncoupling effect results in the leakage of electrons and partial reduction of molecular oxygen in form of superoxide ions [36].”