Potential Role of Carotenoids as Antioxidants in Human Health and Disease
By J. Fiedor, K. Burda. Nutrients, 2014
1,283 citations recorded by the source corpus.
Carotenoids constitute a ubiquitous group of isoprenoid pigments. They are very efficient physical quenchers of singlet oxygen and scavengers of other reactive oxygen species. Carotenoids can also act as chemical quenchers undergoing irreversible oxygenation. The molecular mechanisms underlying these reactions are still not fully understood, especially in the context of the anti- and pro-oxidant activity of carotenoids, which, although not synthesized by humans and animals, are also present in their blood and tissues, contributing to a number of biochemical processes. The antioxidant potential of carotenoids is of particular significance to human health, due to the fact that losing antioxidant-reactive oxygen species balance results in “oxidative stress”, a critical factor of the pathogenic processes of various chronic disorders. Data coming from epidemiological studies and clinical trials strongly support the observation that adequate carotenoid supplementation may significantly reduce the risk of several disorders mediated by reactive oxygen species. Here, we would like to highlight the beneficial (protective) effects of dietary carotenoid intake in exemplary widespread modern civilization diseases, i.e., cancer, cardiovascular or photosensitivity disorders, in the context of carotenoids’ unique antioxidative properties.
Subfields: Biochemistry, Organic Chemistry, Physiology
View Paper: https://www.semanticscholar.org/paper/311afdb2c0450967ed31b9a23b6b0d2708f330ce
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Citations in the corpus
- Antioxidants and Antioxidant Enzymes in Higher Plants (2018, background): “This function depends on their structure and chemical properties (Fiedor and Burda 2014).”
- A global perspective on carotenoids: Metabolism, biotechnology, and benefits for nutrition and health. (2018, background): “suppression of the nuclear factor B (NF-B) signaling pathway, and (D) interaction with other transcription factors, notably members of the nuclear receptor (NR) superfamily of ligandmodulated transcription factors, among others [307, 411-415].”
- Oxidative stress, free radicals and antioxidants: potential crosstalk in the pathophysiology of human diseases (2023, background): “The ß-carotene activity towards peroxyl radicals and the stability of other carboncentred radicals are the two main features that provide the carotene molecule with its antioxidant properties (Fiedor and Burda, 2014).”
- Carotenoid metabolism in plants. (2015, neutral): “In humans, carotenoids also serve as antioxidants and reduce age-related macular degeneration of the eye, the leading cause of blindness in the elderly worldwide (Johnson and Krinsky, 2009; Fiedor and Burda, 2014).”
- The importance of antioxidants which play the role in cellular response against oxidative/nitrosative stress: current state (2015, background): “Vitamin A also has antioxidant properties, which do not, but, show any dependency on oxygen concentration [172].”