Identification of many microRNAs that copurify with polyribosomes in mammalian neurons

By John K. Kim, Anna M. Krichevsky, Yonatan H. Grad, Gabriel D. Hayes, Kenneth S. Kosik, George M. Church, Gary Ruvkun. Proceedings of the National Academy of Sciences of the United States of America, 2003

608 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/0da1f71f2be3a7eed55ff71a246221341c2fafbe

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Citations in the corpus

Mechanisms of axon ensheathment and myelin growth (2005, background): “Base-pairing of these miRNAs to complementary sequences in target RNAs is believed to suppress translation until the granules reach their target sites — for example, dendritic synapse”
Specific MicroRNAs Modulate Embryonic Stem Cell–Derived Neurogenesis (2006, unknown): “Downloaded from www.StemCells.com by Ole Isacson on August 27, 2006 and associated with polysomes in the brain [ 10 , 16], suggesting that they act, at least partially, at the level of translation.”
Regulation of mRNA translation and stability by microRNAs. (2010, background): “Several miRNAs, as well as AGO proteins, have also been reported to be associated with polysomal fractions in both mammalian (11, 115, 119, 120) and plant cells (7).”
mRNA degradation by miRNAs and GW182 requires both CCR4:NOT deadenylase and DCP1:DCP2 decapping complexes. (2006, background): “Other studies have suggested that translation inhibition occurs after initiation, based on the observation that miRNAs and some targets remain associated with polysomes (Olsen and Ambros 1999; Kim et al. 2004; Nelson et al. 2004; Petersen et al. 2006).”
The neuronal microRNA system (2006, background): “, with a diversity of miRNA functions that affect a large number of neuronal gene”
Regulation of miRNA expression during neural cell specification (2005, background): “Lagos-Quintana et al. (2002) have estimated, for example, that mir-124 accounts for 25% to 50% of total adult brain miRNA.”
Microarray profiling of microRNAs reveals frequent coexpression with neighboring miRNAs and host genes. (2005, background): “Based on the specific expression of some miRNAs in mammalian neurons, it has been proposed that miRNAs may regulate translation in mammalian neurons, and that these miRNAs could have roles in synaptic remodeling ( Kim et al. 2004 ).”
Human MicroRNA Targets (2004, background): “In some cases, expression data provide additional support: postsynaptic density protein 95 (PSD95)–associated (SA- PAP4), a neuron-specific protein, is regulated by many miRNAs highly expressed in rat brain primary cortical neurons (Kim et al. 2004).”
MicroRNA-mediated feedback and feedforward loops are recurrent network motifs in mammals. (2007, unknown): “miR-449 Kim et al., 2004 AGCACAAa”
Mechanisms of post-transcriptional regulation by microRNAs: are the answers in sight? (2008, result): “Cosedimentation of a significant fraction of cellular miRNAs or AGO proteins with polysomes has also been reported in other studie”
MicroRNA-124 promotes microglia quiescence and suppresses EAE by deactivating macrophages via the C/EBP-α–PU.1 pathway (2010, unknown): “1 ), the cells expressing the highest miR-124 level”