MicroRNA-mediated feedback and feedforward loops are recurrent network motifs in mammals.

By John S. Tsang, Jun Zhu, Alexander van Oudenaarden. Molecules and Cells, 2007

773 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology, Plant Science

View Paper: https://www.semanticscholar.org/paper/b287e22b5f0486191fc0c9d3b9a9cd4dde1060c6

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Citations in the corpus

MicroRNAs: New Biomarkers for Diagnosis, Prognosis, Therapy Prediction and Therapeutic Tools for Breast Cancer (2015, background): “miRNAs are involved in the functional feedback loop, in which transcription factors influence miRNA expression levels and vice versa [92-94].”
Evolution of microRNA diversity and regulation in animals (2011, background): “Depending on the configuration of the miRNA circuit, different modes of micromanagement are recognize”
Roles for microRNAs in conferring robustness to biological processes. (2012, neutral): “…analyses in fly, fish, and mouse have shown that miRNAs and their targets often have mutually exclusive RNA expression across tissues, especially in neighboring tissues derived from common progenitors (Farh et al., 2005; Stark et al., 2005; Sood et al., 2006; Tsang et al., 2007) (Figure 1).”
MicroRNA control of signal transduction (2010, background): “This might enable the multi-gene regulatory capacity of miRNAs to remodel the signalling landscape, facilitating or opposing the transmission of information to downstream effectors in an effective and timely manne”
Neuronal homeostasis: time for a change? (2011, background): “These loops operate on the level of transcription and translation, and evidence for their existence has been found in all species that have been thus far examined, from prokaryotes to eukaryotes, including humans (Lee et al. 2002; Shen-Orr et al. 2002; Tsang et al. 2007).”
A double-negative feedback loop between ZEB1-SIP1 and the microRNA-200 family regulates epithelial-mesenchymal transition. (2008, background): “enhance the functionality and robustness of gene networks (25, 26).”
MicroRNA Functions in Stress Responses (2010, neutral): “Since many transcription factors regulate the expression of both miRNAs and their mRNA targets (Tsang et al., 2007), we anticipate that the interplay among transcription factors, miRNAs, and their mRNA targets can potentially generate different types of expression timing patterns (Figure 4).”
The bi-functional microRNA miR-9/miR-9* regulates REST and CoREST and is down-regulated in Huntington’s Disease (2008, background): “Double negative feedback networks have been reported in other systems where critical balancing of multiple factors is essential (Tsang et al., 2007).”