Specific MicroRNAs Modulate Embryonic Stem Cell–Derived Neurogenesis

By Anna M. Krichevsky, K. Sonntag, Ole Isacson, Kenneth S. Kosik. Stem Cells, 2006

689 citations recorded by the source corpus.

Subfields: Cancer Research, Developmental Neuroscience, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/40766baa566d9313b5354ef819acea85a819a1c0

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cancer Research

In Molecular Biology

Citations in the corpus

The bi-functional microRNA miR-9/miR-9* regulates REST and CoREST and is down-regulated in Huntington’s Disease (2008, background): “Recent studies on the brain enriched miR-9 have revealed its importance in development and lineage commitment (Sempere et al., 2004; Krichevsky et al., 2006).”
Connecting microRNA genes to the core transcriptional regulatory circuitry of embryonic stem cells (2008, background): “For example, transcript levels of miR-9, a miRNA previously identified in neural cells and that promotes neural differentiation (LagosQuintana et al., 2002; Krichevsky et al., 2006), were significantly elevated in NPCs relative to ES cells, but this miRNA remained scarce in MEFs.”
The Role of MicroRNAs in Human Diseases (2010, background): “Because miRNAs are known to be dynamically regulated in neurogenesis and brain development (107, 108) , it is believed that miRNAs are also involved in neural development and play an important role in mediating neuronal plasticity.”
The neuronal microRNA system (2006, background): “For example, two miRNAs ( miR-124a and miR-9 ) have been implicated in the decision of a mouse neural precursor to adopt a neuronal or glial fat”
The MicroRNA miR-124 promotes neuronal differentiation by triggering brain-specific alternative pre-mRNA splicing. (2007, background): “In combination with the NS-specific miRNA miR-9, miR-124 stimulates neuronal and represses glial differentiation of ES cells in vitro (Krichevsky et al., 2006).”
A MicroRNA Feedback Circuit in Midbrain Dopamine Neurons (2007, background): “in vivo (Kosik and Krichevsky 2005; Krichevsky et al. 2003) or in the context of embryonic stem (ES) cell cultures ( Krichevsky et al. 2006 ).”
Identification of miRNA Changes in Alzheimer's Disease Brain and CSF Yields Putative Biomarkers and Insights into Disease Pathways (2008, neutral): “Expression of miR-9 is necessary for neurogenesis in cultured stem cells and its downregulated expression in presenilin-1 knockout mice correlates with premature cortical differentiation during embryogenesis [36,37, 57].”
MicroRNAs in development and disease. (2011, background): “While miR-124 had no independent effect on stem cell differentiation, it did collaborate with miR-9 to preferentially inhibit the differentiation of progenitors cells into glial cells, while increasing the ratio of neuron to glial cells (318).”