Microarray profiling of microRNAs reveals frequent coexpression with neighboring miRNAs and host genes.

By S. Baskerville, David P. Bartel. RNA: A publication of the RNA Society, 2005

1,506 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/68b6486636977ea049c422d325587d51892f188e

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cancer Research

In Molecular Biology

Citations in the corpus

Role of microRNAs in vascular diseases, inflammation, and angiogenesis. (2008, background): “Then the miRNA transcription depends on the host gene.(1,2) MiRNAs that have their own promoters are independently expressed, and miRNAs organized in clusters share the same transcriptional regulation.”
An Analysis of Human MicroRNA and Disease Associations (2008, background): “MiRNAs separated by ,50 kb showed high coexpression and miRNAs occurring at a distance of more than 50 kb showed low coexpression[22].”
The miR-200 family and miR-205 regulate epithelial to mesenchymal transition by targeting ZEB1 and SIP1 (2008, background): “MiR-200a and miR-200b expression is enriched in tissues where epithelial cell types predominate in human”
The Role of MicroRNAs in Human Diseases (2010, background): “In the nucleus, miRNAs are transcribed as primary pri-miRNA transcripts and then are processed to form the precursor pre-miRNA stem loop structure before transportation into the cytoplasm [where they are cleaved by the Dicer RNAase III endonuclease and produce mature miRNA (21-23 nucleotides] (20) .”
MicroRNAS and their regulatory roles in plants. (2006, background): “This contrasts with animal miRNAs, which sometimes appear to be processed from introns of proteincoding genes (14).”
Prediction of microRNAs Associated with Human Diseases Based on Weighted k Most Similar Neighbors (2013, background): “It has been reported that miRNAs are often found in genomic clusters [33].”
MicroRNAs in human cancer. (2013, background): “These miRNA clusters are co-expressed based on evidence from miRNA profiling data from a variety of tissues and cell lines [22, 33, 34, 49].”
Oncomirs — microRNAs with a role in cancer (2006, background): “The remaining miRNAs are either located far from other transcripts in the genome, within the exons of noncoding mRNA genes or within the 3′ UTRs of mRNA genes, or they are clustered with other miRNA genes, including a cluster on chromosome 19 that is comprised of 54 novel miRNA”
miRNAs in human cancer (2010, background): “These miRNA clusters are co-expressed based on evidence from miRNA profiling data from a variety of tissues and cell lines [22,29,30,40].”
Clustering and conservation patterns of human microRNAs (2005, background): “In a recent study, Baskerville and Bartel (18) demonstrated that proximal pairs of miRNAs tend to coexpress, and that the correlation in expression dropped when the distance between the miRNA pairs exceeded 50 kb.”
MicroRNA expression alterations are linked to tumorigenesis and non-neoplastic processes in pancreatic ductal adenocarcinoma (2007, methodology): “For each pair of sample types (normal, cancer, chronic and cell line), a two-sample t-test assuming equal variance was carried out for every miRNA and multiplicity correction (Benjamini and Hochberg, 1995) was included to control the false discovery rate at 0.05%.”