Tumour invasion and metastasis initiated by microRNA-10b in breast cancer

By W. Warren, LaDeana W. Hillier, J. Graves, Ewan Birney, Chris P. Ponting, F. Grützner, K. Belov, Webb Miller, Laura Clarke, A. Chinwalla and 94 more. Nature, 2008

1,058 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/0c10c07f1b6c624563e5e87a8bc21f54543b8635

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Citations in the corpus

Mammalian Rho GTPases: new insights into their functions from in vivo studies (2008, background): “Expression of mir-10b stimulates invasion in vitro and metastasis in vivo through Rho”
MicroRNA miR-326 regulates TH-17 differentiation and is associated with the pathogenesis of multiple sclerosis (2009, background): “When poorly regulated, microRNAs are critically involved in a range of human disease”
MicroRNAs: key players in the immune system, differentiation, tumorigenesis and cell death (2008, background): “The bHLH transcription factor TWIST, a known inducer of epithelial-to-mesenchymal transition (EMT) and driving force of breast metastases (Yang et al., 2004), induces expression of miR-10b, and this induction indirectly upregulates levels of the prometastatic gene RHOC because miR-10b directly targe”
Genomic profiling of microRNA and mRNA reveals deregulated microRNA expression in prostate cancer (2008, neutral): “<7 (5–6) 15 (25) 8 (27) 7 (23) z7 (7–9) 45 (75) 22 (73) 23 (77) 1.”
MicroRNA control in the immune system: basic principles. (2009, background): “…9, 2009 ©2009 Elsevier Inc. 33 process, including tumor metastasis and cancer stem cell maintenance (Huang et al., 2008; Kent and Mendell, 2006; Ma et al., 2007; Tavazoie et al., 2008; Yu et al., 2007). miRNAs appear also to be heavily involved in the pathogenesis of leukemias and lymphomas.”
The microcosmos of cancer (2012, background): “Micromanagement of metastasis and beyond In addition to promoting cancer initiation, miRNAs can modulate processes that support cancer progression, including metastasi”
Transitions between epithelial and mesenchymal states: acquisition of malignant and stem cell traits (2009, background): “For example, analyses of the expression of candidate miRNAs in metastatic and non-metastatic breast cancer cell lines revealed that miR-10b is a miRNA associated with mesenchymal features and invasive propertie”
Targeting MicroRNAs in Cancer: Rationale, Strategies and Challenges (2010, neutral): “It was determined that miR-10a, which is highly expressed in metastatic breast cancer, positively regulates cell migration and invasio”
MicroRNA-10a binds the 5'UTR of ribosomal protein mRNAs and enhances their translation. (2008, background): “, 2005) and was recently reported to play an important role in breast cancer metastasis via regulation of HOXD10 (Ma et al., 2007).”
Long intergenic non-coding RNAs – New links in cancer progression (2011, background): “Subsequently, Ma and colleagues (33) Tsai et al.”
Improved classification of breast cancer by analysis of genetic alterations and gene expression profiling (2011, background): “For example, over-expression/ knockdown of several miRNAs, including miR-10b, miR-9, miR-31, miR-126 and miR-335, was shown to play a role in metastasis (15, 26, 27, 16).”
Cancer Exosomes Perform Cell-Independent MicroRNA Biogenesis and Promote Tumorigenesis. (2025, positive): “miRNA-21 and -10b have been implicated in breast cancer progression and metastasis (Ma et al., 2007; Yan et al., 2011).”
Ensembl 2009 (2008, background): “Recent genome publications based on Ensembl genesets include those of Platypus Ornithorhynchus anatinus (11), the Oposum Monodelphis domestica (12) and the Rhesus Macaque Macaca mulatta (13).”
Detection of microRNA Expression in Human Peripheral Blood Microvesicles (2008, background): “Later, several studies showed the importance of miRNA in prognosis, initiation and progression of numerous cancer types [16–18].”