MicroRNA control in the immune system: basic principles.

By Changchun Xiao, K. Rajewsky. Cell, 2009

1,087 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/b910c40723535c43f79b8fda627bbaa7a48b3c2c

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Citations in the corpus

MicroRNA miR-326 regulates TH-17 differentiation and is associated with the pathogenesis of multiple sclerosis (2009, background): “Generally, microRNAs are believed to function in vivo by targeting multiple functionally related proteins or a key protein targe”
Unidirectional transfer of microRNA-loaded exosomes from T cells to antigen-presenting cells (2011, background): “Today there is no doubt that miRNAs are important modulators of the immune syste”
Akt1 controls macrophage response to LPS by regulating microRNAs (2009, background): “Recent studies have identified miRNAs as critical regulators of immune responses including inflammation (Baltimore et al., 2008; Chong et al., 2008; Cobb et al., 2006; Liston et al., 2008; Lu et al., 2009; Xiao and Rajewsky, 2009; Zhou et al., 2008).”
MicroRNA function in cancer: oncogene or a tumor suppressor? (2009, background): “Interestingly, the immune system uses miRNAs to regulate development and immune responses [ 23 ].”
MicroRNA-155 promotes autoimmune inflammation by enhancing inflammatory T cell development (2010, background): “Micro-RNAs (miRNAs) are a novel class of non-coding RNAs that modulate gene expression at the posttranscriptional level, and are involved in regulating several aspects of inflammation (O'Connell et al., 2010; Xiao and Rajewsky, 2009).”
Physiological and pathological roles for microRNAs in the immune system (2010, background): “The roles of miRNAs in controlling the early development of B cells are now thought to involve the modulation of key protein factors that control these aspects of B cell developmen”
microRNA regulation of inflammatory responses. (2012, background): “Indeed, examining transgenic mice with differing levels of expression of miR-150, Xiao and colleagues (66, 67) demonstrated a dosage effect on both c-Myb levels and the ensuing phenotype.”
Macrophage phenotypes in atherosclerosis (2014, background): “Small non-coding RNA called microRNAs (miRNAs) play crucial roles in immune and inflammatory responses (118, 119) and modulate many cellular processes including cell proliferation, apoptosis, and differentiation (120, 121).”
Biological functions of microRNAs: a review (2011, background): “Although individual miRNAs modulate protein output from hundreds of target genes, they may impact physiological processes by regulating the concentrations of just a few key cellular proteins, which may be components of a single or of functionally interrelated pathways in a given cellular context [ 7”
Viruses, microRNAs, and Host Interactions (2010, background): “miR-146a can target LPS-activated components, TRAF6 and IRAK1, of the TLR signaling pathway, suggesting a negative-feedback loop to limit innate immune responses (103).”