Mammalian Rho GTPases: new insights into their functions from in vivo studies

By S. Heasman, A. Ridley. Nature reviews. Molecular cell biology, 2008

1,932 citations recorded by the source corpus.

Subfields: Cell Biology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/4c6ef242d772214515bc36d6d9c8d5411d038ce0

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In Cell Biology

1. Qian Li
2. Yi Zhong
3. Ronald L. Davis
4. Xuchen Zhang
5. L. A. Lowery
6. J. Guan
7. P. Lappalainen
8. David Van Vactor

In Molecular Biology

1. Qian Li
2. Yi Zhong
3. Xuchen Zhang
4. Lianzhang Wang
5. L. A. Lowery
6. J. Guan
7. Zhong-Jian Liu
8. P. Lappalainen

Citations in the corpus

• Actin stress fibers – assembly, dynamics and biological roles (2012, background): “The small GTPases RhoA, Rac1 and Cdc42 are the central regulators of actin dynamics in a wide range of eukaryotic organisms (Heasman and Ridley, 2008).”
• Deletion of Cdc42 Enhances ADAM17-Mediated Vascular Endothelial Growth Factor Receptor 2 Shedding and Impairs Vascular Endothelial Cell Survival and Vasculogenesis (2013, background): “Cdc42 can form a complex with Par6, Par3, and atypical protein kinase C (aPKC), and this complex is critical for cell polarity (10, 58).”
• Regulation of Cell Wall Biogenesis in Saccharomyces cerevisiae: The Cell Wall Integrity Signaling Pathway (2011, background): “Members of the Rho (Ras-homologous) family of GTPases play a central role in polarized growth in animal and fungal cells (Drubin and Nelson 1996; Heasman and Ridley 2008).”
• Cdc42-Dependent Forgetting Regulates Repetition Effect in Prolonging Memory Retention. (2016, background): “How can they play distinct roles in forgetting? This idea can be taken further by considering their well-established roles in regulating actin-based protrusions of both non-neuronal cells and neurons, because Cdc42 and Rac1 regulate the formation of filopodia and lamellipodia, respectively (Garvalov”
• Maturation and integration of adult born hippocampal neurons: signal convergence onto small Rho GTPases (2013, background): “Notably, each successive developmental stage is sensitive to a number of extrinsic and intrinsic regulators (Zhao et al., 2008; Ming and Song, 2011).”
• The trip of the tip: understanding the growth cone machinery (2009, background): “, and over 70 GEFs and 80 GAPs have been described in mammal”
• The Biology of Forgetting – A Perspective (2017, background): “Cdc42 is essential for filopodia extensions in developing neurons (Heasman and Ridley, 2008) and may regulate the number of dendritic spines in adult animals (Kim et al.”