Long intergenic non-coding RNAs – New links in cancer progression

By Miao-Chih Tsai, R. Spitale, Howard Y. Chang. Cancer Research, 2011

678 citations recorded by the source corpus.

The process of cancer metastasis consists of a series of sequential and complex steps. Here we give a perspective on recent results of non-coding transcription in cancer progression, focusing on the emerging role of long intergenic non-coding RNAs (lincRNAs). LincRNAs target chromatin modification complexes or RNA binding proteins to alter gene expressing programs. Similar to miRNAs, lincRNAs exhibit distinct gene expression patterns in primary tumors and metastases. We discuss how lincRNAs can be utilized for cancer diagnosis, prognosis, and serve as potential therapeutic targets.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/525188567707ec3a7c6448c4c4aedad591e5d7b1

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cancer Research

1. Howard Y. Chang
2. Zhuhong You
3. Chenggang Clarence Yan
4. Xu Zhang
5. Johannes Rinn
6. Xing Chen
7. M. Gorospe
8. Guodong Yang

In Molecular Biology

1. Howard Y. Chang
2. Zhuhong You
3. Xing Chen
4. Chenggang Clarence Yan
5. Johannes Rinn
6. Xu Zhang
7. M. Gorospe
8. Guodong Yang

Citations in the corpus

• Long non-coding RNAs and complex diseases: from experimental results to computational models (2016, background): “…are transcribed compared with the nearest protein-coding genes) [12] and intronic or intergenic (classified according to the lncRNAs’ relative locations to protein-coding genes: inside the introns of a protein-coding gene or in the interval regions between two protein-coding genes) [12, 71, 72].”
• LncRNA: a link between RNA and cancer. (2014, background): “Accumulating evidence suggests that lncRNAs play an important role in tumorigenesis [11].”
• Long non-coding RNAs: a new frontier in the study of human diseases. (2013, background): “Over the last few decades, research has focused [3].”
• Revealing protein–lncRNA interaction (2015, neutral): “Several other examples can be found in recent reviews [23–27].”
• Long Noncoding RNA MALAT1 Controls Cell Cycle Progression by Regulating the Expression of Oncogenic Transcription Factor B-MYB (2013, background): “A large number of lncRNAs display deregulated expression in human cancer samples and are regulated by oncogenic or tumor suppressor pathways [28,34,35,36,37,38].”
• Genome regulation by long noncoding RNAs (2012, background): “The strongest connection at present is with cancer (119).”