Transitions between epithelial and mesenchymal states: acquisition of malignant and stem cell traits
By K. Polyak, R. Weinberg. Nature Reviews. Cancer, 2009
3,350 citations recorded by the source corpus.
Subfields: Cell Biology, Molecular Biology, Oncology
View Paper: https://www.semanticscholar.org/paper/45b3034527772db0d0e16d7acdd2e690fb8c77f7
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Citations in the corpus
- The molecular mechanisms and therapeutic strategies of EMT in tumor progression and metastasis (2022, background): “The reverse process, which is known as mesenchymal–epithelial transformation (MET), occurs frequently during development (such as heart development, kidney morphogenesis, and somite formation) and cancer [1].”
- MicroRNA control of signal transduction (2010, background): “However, in epithelium-derived tumours, EMT is usurped to foster metastasis and gain of cancer stem cell phenotype”
- EMT, MET, plasticity and tumor metastasis (2020, background): “In turn, mesenchymal-epithelial transition (MET) is the reversion of EMT and is apparent during development, induced pluripotent stem cell reprogramming and tumor metastasis [3].”
- The ins and outs of the epithelial to mesenchymal transition in health and disease. (2011, background): “In the past few years, the EMT has been recognized as a crucial step in the metastatic cascade (Polyak & Weinberg 2009, Thiery et al. 2009).”
- Collective Invasion in Breast Cancer Requires a Conserved Basal Epithelial Program (2013, background): “A central problem in collective invasion is how a group of adherent epithelial cancer cells acquires motile invasive behavior (Friedl and Gilmour, 2009; Gray et al., 2010; Polyak and Weinberg, 2009).”
- Epithelial-mesenchymal transitions: insights from development (2012, background): “The role of EMT in tumor progression has been repeatedly emphasized, including the transient acquisition of stemness (Polyak and Weinberg, 2009; Thiery et al., 2009; Valastyan and Weinberg, 2011).”
- Tumors as organs: complex tissues that interface with the entire organism (2010, positive): “The microenvironments in areas of low oxygen/low pH and at the tumor-stroma edge appear particularly capable of selecting for or inducing cancer cells with more invasive properties (Hermann et al., 2007; Polyak and Weinberg, 2009; Staller et al., 2003).”
- Immunity, Inflammation, and Cancer (2010, background): “Finally, single metastatic progenitors interact with immune, inflammatory, and stromal cells and start to proliferate (Polyak and Weinberg, 2009).”
- TGF-&bgr; signaling and epithelial–mesenchymal transition in cancer progression (2013, background): “It plays a key role in initiating carcinoma cell invasion that will lead to cancer cell dissemination [6,14,45].”
- Hallmarks of cancer: the next generation. (2011, positive): “…become prominently implicated as a means by which transformed epithelial cells can acquire the abilities to invade, to resist apoptosis, and to disseminate (Klymkowsky and Savagner, 2009; Polyak and Weinberg, 2009; Thiery et al., 2009; Yilmaz and Christofori, 2009; Barrallo-Gimeno and Nieto, 2005).”
- The Roles of Autophagy in Cancer (2018, background): “These processes induce metastasis of cancer, leading to a lack of cell-cell adhesion, cell polarity to increase of cell motility, polarity, and invasiveness [111,112].”
- Mathematical Modelling of Molecular Pathways Enabling Tumour Cell Invasion and Migration (2015, background): “These transcription factors activate other genes that initiate EMT [11–13] and are induced by several signalling pathways including TGF-β, NF-κB, Wnt and Notch pathways [8,14,15].”