Bile Salt Hydrolase Activity in Probiotics

By M. Begley, C. Hill, C. Gahan. Applied and Environmental Microbiology, 2006

1,154 citations recorded by the source corpus.

Subfields: Food Science, Genetics, Nutrition and Dietetics

View Paper: https://www.semanticscholar.org/paper/091d0bb95025c67d7371c29811e4d7b5cabf5bd5

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Citations in the corpus

Novel isolates of lactobacilli from fermented Portuguese olive as potential probiotics (2014, background): “In fact, BSH activity has not yet been detected in bacteria isolated from environments devoid of bile salts e as is the case of olive brines (Begley et al., 2006).”
Functional and comparative metagenomic analysis of bile salt hydrolase activity in the human gut microbiome (2008, background): “Free primary BAs are subsequently open to a wider pathway of BA modification encoded by the gut microbiota, which generates secondary and tertiary forms through dehydroxylation, dehydrogenation, and sulfation (9, 10, 16, 17).”
In vitro assessment of safety and probiotic potential characteristics of Lactobacillus strains isolated from water buffalo mozzarella cheese (2017, background): “Additionally, bile disturbs the stability of macromolecules, including RNA, DNA and proteins, and may cause oxidative stress (Begley et al. 2006).”
Effects of Probiotics, Prebiotics, and Synbiotics on Human Health (2017, background): “, Lactobacillus and Bifidobacterium) may produce the so-called de-conjugated bile acids (derivatives of bile acids), demonstrating stronger antibacterial effect than the bile salts produced by their host [28,56].”
Bacteroides: the Good, the Bad, and the Nitty-Gritty (2007, background): “, unconjugated bile acids are less efficient than conjugated molecules in digestion of lipids) effects for the host (17).”
Cholesterol-Lowering Effects of Probiotics and Prebiotics: A Review of in Vivo and in Vitro Findings (2010, background): “Cholesterol is used to synthesize new bile acids in a homeostatic response, resulting in lowering of serum cholesterol [85] (Figure 1).”
Consequences of bile salt biotransformations by intestinal bacteria (2016, background): “Not surprisingly, therefore, much literature in probiotics is devoted to screening potential probiotic bacteria for BSH activity and specificity.(55)”
Selection of potential probiotic lactic acid bacteria from fermented olives by in vitro tests. (2013, background): “Indeed some strains of LAB secrete bile salt hydrolase enzyme, which hydrolyses conjugated bile acids to release de-conjugated bile acids and amino acids (Sridevi et al., 2009; Begley et al., 2006; Franz et al., 2011).”
Screening of isolated potential probiotic lactic acid bacteria for cholesterol lowering property and bile salt hydrolase activity (2016, result): “Contrary to the results of the present study, Begley et al. (2006) reported that BSH activity has not been detected in bacteria isolated from environments from which bile salts are absent.”
The human gut microbiota: Metabolism and perspective in obesity (2018, background): “Bifidobacterium species have been shown to deconjugate bile acids, which may decrease fat absorption.(95) In contrast, strains of the same species can have contradictory effects, as it has been shown that different Bifidobacterium strains might increase (strain M13–4) or decrease body weight (strain”