Functional and comparative metagenomic analysis of bile salt hydrolase activity in the human gut microbiome

By B. Jones, M. Begley, C. Hill, C. Gahan, Julian R. Marchesi. Proceedings of the National Academy of Sciences of the United States of America, 2008

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Bile Acid Signaling in Metabolic Disease and Drug Therapy (2014, background): “In the intestine, bacterial BSHs deconjugate conjugated bile acids and are enriched in the human gut microbiome (Jones et al., 2008).”
Intestinal Crosstalk between Bile Acids and Microbiota and Its Impact on Host Metabolism. (2016, positive): “ated with increased resistance to bile toxicity (Jones et al., 2008).”
Stress Physiology of Lactic Acid Bacteria (2016, background): “Some probiotic LAB can efficiently express a range of bile salt hydrolases (BSH) that confer protection against bile via bile salt deconjugation (471).”
Gut microbiota functions: metabolism of nutrients and other food components (2017, methodology): “[63] used this methodology to study the distribution of BSH”
Consequences of bile salt biotransformations by intestinal bacteria (2016, background): “Metagenomic “mining” of environmental bacteria for BSH and characterization of cloned homologues revealed penicillin V amidase activity, but not BSH activity, suggesting BSH is a gut-specific function.(20)”