MicroRNA-directed transcriptional gene silencing in mammalian cells

By Daniel H. Kim, Pål Sætrom, O. Snøve, John J. Rossi. Proceedings of the National Academy of Sciences of the United States of America, 2008

749 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/08309929806a3efcc303bcbc53e09eacf0b6c2d5

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Citations in the corpus

MicroRNA control in the immune system: basic principles. (2009, background): “, 2007) or even directly interfere with gene transcription (Kim et al., 2008).”
miRNA‐dependent gene silencing involving Ago2‐mediated cleavage of a circular antisense RNA (2011, background): “It has been shown that promoter-targeting siRNAs can induce TGS in cultured human cell lines as well (Morris et al, 2004), and recently an endogenous mammalian TGS mechanism involving miRNAs has been proposed (Gonzalez et al, 2008; Kim et al, 2008).”
Small RNAs in transcriptional gene silencing and genome defence (2009, background): “Furthermore, recent studies describe a role for promoter-directed human miRNAs in facilitating repressive chromatin modifications and TG”
Targeting MicroRNAs in Cancer: Rationale, Strategies and Challenges (2010, neutral): “Three studies have reported that miRNAs can also regulate gene expression at the transcriptional level by binding directly to the DN”
The widespread regulation of microRNA biogenesis, function and decay (2010, background): “; and there is some evidence that miRNAs may also play a role in transcriptional silencing in mammalian cell”
Biogenesis, Turnover, and Mode of Action of Plant MicroRNAs[OPEN] (2013, background): “DNA Methylation In addition to posttranscriptional gene silencing, miRNAs both in plants (Wu et al., 2010) and in animals (D.H. Kim et al., 2008; Khraiwesh et al., 2010) are capable of transcriptional gene silencing (Figure 2).”
The rise of regulatory RNA (2014, background): “…is more complex and multifaceted than expected, with (for example) demonstrations that miRNA isoforms are developmentally regulated 89 that the target ‘seed’ sequence is only one factor in target recognition 90,91 , and that miRNAs can also act to impose transcriptional silencing 92 (Figure 2).”
The promises and pitfalls of RNA-interference-based therapeutics (2009, neutral): “Most recently, a miRNA (miR-320) has been shown to regulate transcription of the POLR3D subunit of RNA polymerase III (Pol III”
Human box C/D snoRNAs with miRNA like functions: expanding the range of regulatory RNAs (2010, background): “A role in transcriptional regulation for an endogenous miRNA was recently discovered (10,11) and previously shown for exogenously delivered siRNAs (12,13).”
Many roads to maturity: microRNA biogenesis pathways and their regulation (2009, background): “The re-import of miRNAs into the nucleus is especially relevant because evidence is accumulating that miRNAs could regulate gene expression in the nucleus at the transcriptional leve”
MicroRNA dysregulation in cancer: diagnostics, monitoring and therapeutics. A comprehensive review (2012, neutral): “Three studies have reported that miRNAs can also regulate gene expression at the transcriptional level by direct binding to the DNA (Gonzalez et al, 2008; Khraiwesh et al, 2010; Kim et al, 2008).”