Costimulatory signals mediated by the ITAM motif cooperate with RANKL for bone homeostasis

By T. Koga, M. Inui, Kazuya Inoue, Sunhwa Kim, Ayako Suematsu, E. Kobayashi, T. Iwata, H. Ohnishi, T. Matozaki, T. Kodama and 3 more. Nature, 2004

855 citations recorded by the source corpus.

Subfields: Cancer Research, Immunology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/079f79f3d614d52d93fd1e8e4bebd9938a0896e3

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In Cancer Research

1. M. Colonna
2. S. Teitelbaum
3. Hiroshi Takayanagi
4. D. Cua
5. Shizuo Akira
6. Taro Kawai
7. R. Medzhitov
8. K. Takeda

In Immunology

1. Shizuo Akira
2. Y. Iwakura
3. M. Colonna
4. Hiroshi Takayanagi
5. D. Cua
6. B. Boyce
7. L. Xing
8. A. Mócsai

In Molecular Biology

1. J. Smolen
2. M. Colonna
3. L. Xing
4. B. Boyce
5. Hiroshi Takayanagi
6. Soo Young Lee
7. K. Redlich
8. N. Lee

Citations in the corpus

• Current Understanding of RANK Signaling in Osteoclast Differentiation and Maturation (2017, background): “Cells 2017; 40(10): 706-713 709 the nucleus where it binds with DNA in combination with other transcription factors to upregulate the transcription of NFATc1 target genes (Koga et al., 2004).”
• The SYK tyrosine kinase: a crucial player in diverse biological functions (2010, background): “, whereas mice lacking both DAP12 and FcRγ show severe osteopetrosi”
• Osteoclasts: what do they do and how do they do it? (2007, positive): “These events occur in the context of the ITAM proteins, Dap12 and FcR , which when deleted in tandem arrest terminal osteoclastogenesis because of failed expression of the critical osteoclastogenic transcription factor, NFATc1.”
• Th17 functions as an osteoclastogenic helper T cell subset that links T cell activation and bone destruction (2006, background): “Th1 and Th2 cells both had less suppressive eff ects in the co-culture system, possibly because osteoblasts provide protection against the inhibitory eff ects through costimulatory signals (27) (see Discussion).”
• Osteoimmunology: shared mechanisms and crosstalk between the immune and bone systems (2007, background): “An osteopetrotic phenotype observed in mice deficient in both FcRγ and DAP12 led to the designation of immunoglobulin-like receptors as crucial co-stimulatory molecules for RAN”
• Inflammatory bone loss: pathogenesis and therapeutic intervention (2012, background): “NFATC1, which is also partly activated by FOS-mediated signalling, is an important transcription factor for osteoclast generatio”
• Biology of RANK, RANKL, and osteoprotegerin (2007, background): “common γ subunit (FcRγ) immunoreceptor expressed by osteoclasts and the adapter protein DNAX-activating protein 12, which associates with an immunoreceptor tyrosine-based activation motif [44].”
• The TREM receptor family and signal integration (2006, background): “Many signaling pathways act in osteoclastogenesis, including the M-CSF–M-CSFR, RANK-RANKL and ITAM pathway”
• The molecular triad OPG/RANK/RANKL: involvement in the orchestration of pathophysiological bone remodeling. (2004, background): “[129] revealed that RANKL and M-CSF were not sufficient to activate the signals required for osteoclastogenesis.”