The TREM receptor family and signal integration

By J. Klesney-Tait, Isaiah R. Turnbull, M. Colonna. Nature Immunology, 2006

608 citations recorded by the source corpus.

Subfields: Immunology, Pharmacology

View Paper: https://www.semanticscholar.org/paper/b8bb7713e4e70f94547b3b72e131344b945e1dfe

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

1. B. Guy
2. T. Wyss‐Coray
3. Gordon D. Brown
4. M. Colonna
5. Michael T. Heneka
6. C. Reis e Sousa
7. Shizuo Akira
8. R. Medzhitov

In Pharmacology

1. T. Wyss‐Coray
2. Henrik Zetterberg
3. Michael T. Heneka
4. Christian Haass
5. José Luis Molinuevo

Citations in the corpus

• TREM2 mutations implicated in neurodegeneration impair cell surface transport and phagocytosis (2014, background): “The TREM2 homolog TREM1 is found as a soluble variant in the serum of patients with septic shock and is secreted from monocytes upon stimulation with lipopolysaccharide (15).”
• Syk- and CARD9-dependent coupling of innate immunity to the induction of T helper cells that produce interleukin 17 (2007, background): “Finally, the central function of Syk in DC activation by means of C-type lectin PRRs raises the issue of whether other receptors that engage Syk in myeloid cells, such as TREM protein”
• Platelets and the immune continuum (2011, background): “TREM1 belongs to the V-type immunoglobulin superfamily and is primarily expressed by neutrophils and monocyte”
• Alzheimer’s Disease Risk Gene CD33 Inhibits Microglial Uptake of Amyloid Beta (2013, unknown): “TREM2 is an innate immune receptor, similar to CD33, and is expressed in a subset of myeloid cells including microglia (Klesney-Tait et al., 2006).”
• A cytokine-mediated link between innate immunity, inflammation, and cancer. (2007, unknown): “…that recognize PAMPs have been identified; these are known as pattern recognition receptors (PRRs) and include TLRs, nucleotide-binding oligomerization domain–like (NOD-like) receptors (NLRs), C-type lectin receptors (CLRs), and triggering receptors expressed on myeloid cells (TREMs) (24–27).”
• The perfect mix: recent progress in adjuvant research (2007, background): “Finally, TREMs have been characterized as amplifiers of immune responses but so far their specific ligands have not been identifie”