Osteoclasts: what do they do and how do they do it?

By S. Teitelbaum. American Journal of Pathology, 2007

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Biology of Bone Tissue: Structure, Function, and Factors That Influence Bone Cells (2015, background): “The products of this degradation are then endocytosed across the ruffled border and transcytosed to the functional secretory domain at the plasma membrane [7, 95].”
Osteal Tissue Macrophages Are Intercalated throughout Human and Mouse Bone Lining Tissues and Regulate Osteoblast Function In Vitro and In Vivo1 (2008, background): “2C) in conditions where no exogenous CSF-1 (a required macrophage survival factor in vitro) was added.”
Mechanisms of Bone Resorption in Periodontitis (2015, background): “Following this, the activated osteoclasts attach to the bone matrix and their cytoskeleton reorganizes; they take on a polarized morphology and form a sealing zone to isolate the resorption site and develop ruffled borders which secrete protease enzymes [9, 14, 20, 31].”
Molecular Inflammation: Underpinnings of Aging and Age-related Diseases (2008, background): “osteoclasts are stem cell from a fusion of myeloid-derived immune cells, such as monocytes (Teitelbaum, 2007).”