The SYK tyrosine kinase: a crucial player in diverse biological functions

By A. Mócsai, J. Ruland, V. Tybulewicz. Nature reviews. Immunology, 2010

1,339 citations recorded by the source corpus.

Spleen tyrosine kinase (SYK) is known to have a crucial role in adaptive immune receptor signalling. However, recent reports indicate that SYK also mediates other, unexpectedly diverse biological functions, including cellular adhesion, innate immune recognition, osteoclast maturation, platelet activation and vascular development. SYK is activated by C-type lectins and integrins, and activates new targets, including the CARD9–BCL-10–MALT1 pathway and the NLRP3 inflammasome. Studies using Drosophila melanogaster suggest that there is an evolutionarily ancient origin of SYK-mediated signalling. Moreover, SYK has a crucial role in autoimmune diseases and haematological malignancies. This Review summarizes our current understanding of the diverse functions of SYK and how this is being translated for therapeutic purposes.

Subfields: Immunology

View Paper: https://www.semanticscholar.org/paper/6bf5bc8378101a29caec38244c6fa4e4842a9ef8

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Citations in the corpus

• Neutrophils to the ROScue: Mechanisms of NADPH Oxidase Activation and Bacterial Resistance (2017, background): “Ligation and crosslinking of Fc receptors leads to the phosphorylation of the ITAMs by Src family kinases (SFKs) resulting in the recruitment and the tyrosine phosphorylation of the Src homology domain of Syk.”
• Toll-like receptors and their crosstalk with other innate receptors in infection and immunity. (2011, background): “…during infection with L. major, T. brucei, T. cruzi, P. berghei, P. falciparum, and T. gondii, suggesting that multiple TLRs orchestrate the protective responses (Adachi et al., 2001; Bafica et al., 2006; Coban et al., 2007; Kropf et al., 2004; Mun et al., 2003; Ropert and Gazzinelli, 2004).”
• Macrophage defense mechanisms against intracellular bacteria (2015, background): “Kant AM, et al. SHP-1 regulates Fcgamma receptor-mediated phagocytosis and the activation of RAC.”
• Neutrophil cell surface receptors and their intracellular signal transduction pathways (2013, background): “Receptor ligation leads to phosphorylation of the ITAM/ hemITAM tyrosine residues, leading to recruitment and activation of Syk [61].”