Micromanagers of gene expression: the potentially widespread influence of metazoan microRNAs

By David P. Bartel, Chang‐Zheng Chen. Nature reviews genetics, 2004

1,514 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/06ede589d76b72a200eeabd43e2010d31d4d6cd2

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Citations in the corpus

Control of translation and mRNA degradation by miRNAs and siRNAs. (2006, background): “…repression by miRNAs often utilizes multiple miRNA-binding sites, This was first suggested by the observation that the early identified mRNA targets of miRNAs contained multiple sites for miRNA binding, either the same miRNA or a combination of several different miRNAs (Bartel and Chen 2004).”
Evolution of microRNA diversity and regulation in animals (2011, background): “Thus, there are pools of genes called 'anti-targets' (Ref”
Human MicroRNA Targets (2004, background): “…adaptors guiding RNPs to particular target sequences. miRNA regulation of cellular messages may therefore range from a switchlike behavior (e.g., cleavage of mRNA message) to a subtle modulation of protein dosage in a cell through low-level translational repression (Bartel and Chen 2004).”
Genomics of microRNA. (2006, background): “As Bartel and Chen proposed, the unique combination of miRNAs expressed in each cell type might affect or ‘dampen’ the use of thousands of target mRNAs [ 99 ].”
MicroInspector: a web tool for detection of miRNA binding sites in an RNA sequence (2005, background): “In Arabidopsis thaliana, this approach was quite successful, since plant miRNAs seem to base-pair with higher stringency (23,24).”
MicroRNA-mediated feedback and feedforward loops are recurrent network motifs in mammals. (2007, background): “Under conditions in which the target genes are transcriptionally suppressed, such circuits can serve as a surveillance mechanism to suppress ''leaky'' transcription of target genes (Bartel and Chen, 2004; Hornstein and Shomron, 2006; Stark et al., 2005).”
Principles of MicroRNATarget Recognition (2005, background): “]. Our estimate of the total number of targets approaches the number of protein-coding genes, suggesting that regulation of gene expression by miRNAs plays a greater role in biology than previously anticipated. Indeed, Bartel and Chen [”
Microarray analysis shows that some microRNAs downregulate large numbers of target mRNAs (2005, result): “Our results provide experimental support for the hypothesis that vertebrate miRNA targets are plentiful in numbe”
MicroRNA control of signal transduction (2010, background): “We now know that miRNAs are a universal and pervasive feature of animal and plant genomes; current estimates suggest that the human genome contains at least hundreds of distinct miRNAs, which potentially regulate a large fraction of the transcriptom”
MicroRNA biogenesis: coordinated cropping and dicing (2005, background): “Consequently, the unique combination of miRNAs that are expressed in each cell type might affect or 'dampen' the utilization of thousands of mRNA”
MicroRNA function: multiple mechanisms for a tiny RNA? (2005, background): “With the number of predicted miRNA targets running into the thousands, miRNAs might very well form another layer of the regulatory circuitry that exists in the cell (Bartel and Chen 2004).”