Microarray analysis shows that some microRNAs downregulate large numbers of target mRNAs

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A polycistronic microRNA cluster, miR-17-92, is overexpressed in human lung cancers and enhances cell proliferation. (2005, background): “through microarray analysis that miRNAs can indeed affect expression levels of an enormous number of genes (15).”
Position-specific chemical modification of siRNAs reduces "off-target" transcript silencing. (2006, background): “1197 disrupt regulation of unintended transcripts, just as mismatches disrupt miRNA target regulation (Doench and Sharp 2004; Lim et al. 2005).”
Posttranscriptional regulation of microRNA biogenesis in animals. (2010, background): “Since then, thousands of miRNAs have been found in animals, plants, and unicellular eukaryotes, and it is becoming clear that miRNAs have a big impact on shaping transcriptomes and proteomes of eukaryotic organisms (Baek et al., 2008; Lim et al., 2005; Selbach et al., 2008).”
Prediction and validation of microRNAs and their targets (2005, unknown): “Microarrays have now been shown, by several independent groups, to be an eﬀective, sensitive and speciﬁc means of high-throughput detection of expression microRNAs [24,29– 35].”
A genetic screen implicates miRNA-372 and miRNA-373 as oncogenes in testicular germ cell tumors. (2006, background): “To start to identify relevant targets of miR-372&3, we took advantage of the fact that miRNAs may cause limited destruction of their target mRNAs apart from inhibiting their translation (Lim et al., 2005).”