MicroRNA biogenesis: coordinated cropping and dicing

By V. Narry Kim. Nature reviews. Molecular cell biology, 2005

2,612 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/f1f962207138ee6c211c0b5b04be2aab62f15f6e

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Citations in the corpus

Mechanisms of miRNA-Mediated Gene Regulation from Common Downregulation to mRNA-Specific Upregulation (2014, background): “They can reach several kilobases in length [46].”
DNA methylation mediated by a microRNA pathway. (2010, background): “In animals, the maturation of an miRNA from its pri-miRNA involves two sequential processing steps: (1) the pri-miRNA is processed into an miRNA precursor (premiRNA) by RNase III family enzyme Drosha in the nucleus, and (2) the pre-miRNA is exported into the cytoplasm, where it is further processed ”
Lin28 mediates the terminal uridylation of let-7 precursor MicroRNA. (2008, background): “MiRNA processing is initiated by nuclear RNase III Drosha and completed by cytoplasmic RNase III Dicer (Kim, 2005).”
MicroRNAs: key players in the immune system, differentiation, tumorigenesis and cell death (2008, background): “These topics have been reviewed in detail elsewhere (Bartel, 2004; Kim, 2005; Engels and Hutvagner, 2006; Zeng, 2006). miRNA biogenesis requires several posttranscriptional processing steps to yield the functional mature miRNA.”
Origins and Mechanisms of miRNAs and siRNAs (2009, background): “Transcription of miRNAs is typically performed by RNA polymerase II, and transcripts are capped and polyadenylated (Kim, 2005).”
Control of translation and mRNA degradation by miRNAs and siRNAs. (2006, background): “Although both types of molecules can be functionally equivalent, they are distinguished by their mode of biogenesis (Carmell and Hannon 2004; Kim 2005). miRNAs are produced from transcripts that form stem-loop structures.”
Genetic variation in microRNA networks: the implications for cancer research (2010, neutral): “Our knowledge and understanding of miRNA biogenesis has evolved in recent years, and is thoroughly described elsewher”
A construct with fluorescent indicators for conditional expression of miRNA (2008, neutral): “Many natural miRNAs are in introns of protein-encoding genes [24].”
MicroRNA control in the immune system: basic principles. (2009, background): “The usual consequence of miRNA:mRNA interaction is the downregulation of protein expression by translational repression, mRNA cleavage, or promotion of mRNA decay (Kim, 2005).”
MicroRNAs in Common Human Diseases (2012, background): “Through painstaking characterization of miRNA biogenesis and functional pathways [18], it is now clear that miRNAs repress the expression of cellular gene targets in a sequence-dependent manner.”
TRBP, a regulator of cellular PKR and HIV‐1 virus expression, interacts with Dicer and functions in RNA silencing (2005, background): “Dicer is also responsible for the excision of siRNAs from double-stranded (ds)RNA (Kim, 2005; Tomari & Zamore, 2005).”