Genomics of microRNA.

By V. Narry Kim, Jin-Wu Nam. Trends in Genetics, 2006

957 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/c9c30c57b4df1098aedd7d5b6dbfcb4a67c37191

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Citations in the corpus

miRGen: a database for the study of animal microRNA genomic organization and function (2006, background): “After a pri-miRNA is transcribed, precursor miRNA (pre-miRNA) hairpin structures are cleaved from the transcript and exported to the cytoplasm where the final ‘mature’ miRNAs of 19–24 nt are produced (17,18).”
Genome-wide transcription and the implications for genomic organization (2007, background): “A key element in using RNA as a regulatory agent is its full or partial sequence complementarity to the targe”
The TEAD/TEF family protein Scalloped mediates transcriptional output of the Hippo growth-regulatory pathway. (2008, background): “, 2005), and microRNA promoters are less well defined than those of protein-coding genes (Kim and Nam, 2006).”
Specialization and evolution of endogenous small RNA pathways (2007, background): “miRNA genes are most often transcribed by RNA polymerase II (PolII), can form in mono- or polycistronic configurations, and occur in both intronic and exonic sequence”
MicroRNA signatures in human cancers (2006, background): “The biogenesis of miRNAs involves a complex protein system, including members of the Argonaute family, Pol II-dependent transcription and the RNase IIIs Drosha and Dicer”
Identification of 22 candidate structured RNAs in bacteria using the CMfinder comparative genomics pipeline (2007, neutral): “The following eight groups were used: (1) Firmicutes, ( 2 ) Actinobacteria, (3) a-proteobacteria, (4) b-proteobacteria, (5) g-proteobacteria, (6) d- and e-proteobacteria, (7) Cyanobacteria and (8) Bacteroidetes, Chlorobi, Chlamydiae, Verrucomicrobia and Spirochaetes.”
A guide through present computational approaches for the identification of mammalian microRNA targets (2006, methodology): “For a detailed description of the biogenesis and targeting mechanisms of miRNAs we direct the reader to several of the many comprehensive reviews on the topi”
miRanalyzer: a microRNA detection and analysis tool for next-generation sequencing experiments (2009, background): “First, the mapping against the transcriptome should not yield any matches except for exonic microRNAs (1).”
Mechanisms of miRNA-Mediated Gene Regulation from Common Downregulation to mRNA-Specific Upregulation (2014, background): “…have been a subject of significant research work since the discovery of lin-4 in the early 1990s, underscoring the importance of posttranscriptional gene regulation in cis and trans [1]. miRNAs are a subset of endogenously-initiated, single-stranded noncoding RNA guide molecules, traceable…”
Aberrant Expression of Oncogenic and Tumor-Suppressive MicroRNAs in Cervical Cancer Is Required for Cancer Cell Growth (2008, background): “uk/sequences, 2006) have now been identified in the human [41,42] [43,44] , and their functions are beginning to be elucidated [45].”
MiR-133b promotes neural plasticity and functional recovery after treatment of stroke with multipotent mesenchymal stromal cells in rats via transfer of exosome-enriched extracellular particles (2013, neutral): “The miRNA regulation is a network system [13, 99], and the transcription of miRNAs may be regulated [100, 101].”