Posttranslational mechanisms regulate the mammalian circadian clock.

By Choogon Lee, J. Etchegaray, F. Cagampang, A. Loudon, Steven M. Reppert. Cell, 2001

1,193 citations recorded by the source corpus.

Subfields: Aging, Endocrine and Autonomic Systems, Plant Science

View Paper: https://www.semanticscholar.org/paper/05901afb64fc762bfa52375672b2970e938265bd

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Citations in the corpus

Physiology of circadian entrainment. (2010, background): “Mutations in both ck1 and ck1 induce profound changes in circadian period by altering both the accumulation of protein in the cytoplasm as well as nuclear translocation of the dimers (10, 127, 129, 270).”
The Genetics of Mammalian Circadian Order and Disorder: Implications for Physiology and Disease (2008, background): “The resulting PER and CRY proteins heterodimerize, translocate to the nucleus and interact with the CLOCK–BMAL1 complex to inhibit their own transcriptio”
A functional genomics strategy reveals Rora as a component of the mammalian circadian clock. (2004, background): “…Cry levels, Bmal14 Laboratory of Neuronal Structure and Function also displays circadian regulation of its steady-stateSalk Institute mRNA levels (Lee et al., 2001; Shearman et al., 2000),10010 North Torrey Pines Road which is controlled in part by the orphan nuclear recep-La Jolla, California…”
System-Driven and Oscillator-Dependent Circadian Transcription in Mice with a Conditionally Active Liver Clock (2007, background): “The varying mPER1 migration is probably due to oscillating protein phosphorylation and dephosphorylation (see [18]).”
SIRT1 regulates circadian clock gene expression through PER2 deacetylation. (2008, neutral): “expression as well as changes in BMAL1 phosphorylation were observed (Figure 1A) (Kornmann et al., 2007; Lee et al., 2001; Preitner et al., 2002; Ripperger and Schibler, 2006).”
Rhythmic histone acetylation underlies transcription in the mammalian circadian clock (2003, background): “The Cry proteins feedback to inhibit Clock/Bmal1-mediated transcription by a mechanism that does not alter Clock/Bmal1 binding to DN”
The NAD+-Dependent Deacetylase SIRT1 Modulates CLOCK-Mediated Chromatin Remodeling and Circadian Control (2008, background): “The CLOCK protein is one of the few core circadian regulators whose levels do not oscillate in most settings (Lee et al., 2001).”
Functional consequences of a CKIδ mutation causing familial advanced sleep phase syndrome (2005, background): “Multiple points of regulation have been proposed, including the nuclear import and export of circadian proteins, and the active/inactive states of these proteins, but the details of this system are not well understoo”
Control of Mammalian Circadian Rhythm by CKIε-Regulated Proteasome-Mediated PER2 Degradation (2005, background): “mPER2 also undergoes temporal changes in phosphorylation that reaches a zenith just prior to its destruction (25).”
Coordination of circadian timing in mammals (2002, neutral): “Clock protein phosphorylation CLOCK, BMAL1, mPER1 and mPER2 undergo temporal changes in phosphorylation in vivo , with maximal phosphorylation correlating with the time of negative feedback on mPer / mCry transcriptio”
Circadian regulator CLOCK is a histone acetyltransferase. (2006, neutral): “Paradoxical to the central role played by CLOCK in the rhythmic transcription of the clock-controlled genes, expression of CLOCK is described to be nearly constitutive (Lee et al., 2001; Ripperger and Schibler, 2006).”