Autophagy in metazoans: cell survival in the land of plenty

By J. Lum, Ralph J. Deberardinis, Craig B. Thompson. Nature reviews. Molecular cell biology, 2005

838 citations recorded by the source corpus.

Subfields: Epidemiology, Plant Science, Surgery

View Paper: https://www.semanticscholar.org/paper/04c18364f32a37fa7d220406374ddce4571fc896

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Citations in the corpus

Autophagy inhibition enhances therapy-induced apoptosis in a Myc-induced model of lymphoma. (2007, background): “Autophagy has been reported to promote cell survival in response to stress through both its ability to clear damaged organelles (25) and its ability to recycle intracellular contents to maintain bioenergetics (26).”
Self-eating and self-killing: crosstalk between autophagy and apoptosis (2007, background): “By the catabolism of macromolecules, autophagy generates metabolic substrates that meet the bioenergetic needs of cells and thereby allows for adaptive protein synthesi”
Mechanisms of Life Span Extension by Rapamycin in the Fruit Fly Drosophila melanogaster (2010, background): “Under starvation, TORC1 additionally promotes autophagy, a critical process for supplying starving cells with bioenergetic components (Lum et al., 2005).”
Linking of autophagy to ubiquitin-proteasome system is important for the regulation of endoplasmic reticulum stress and cell viability. (2007, background): “Although both UPS and autophagy serve to degrade intracellular contents, the two systems are generally thought to be independent from each other in terms of the degradation mechanisms, the types of contents to be degraded, the signals activating the pathway, and the physiological significance of the”
Autophagy gene-dependent clearance of apoptotic cells during embryonic development. (2007, methodology): “One of the important functions of autophagy is to maintain cellular bioenergetics in cells subjected to nutrient deprivation and potentially other forms of stress (Lum et al., 2005b).”
Bcl-2 family proteins and cancer (2008, background): “Prolonged nutrient deprivation invokes autophagy, an evolutionarily conserved response for catabolizing macromolecules and organelles, thereby generating substrates for ATP production (Edinger and Thompson, 2004; Lum et al., 2005).”
Cardiac autophagy is a maladaptive response to hemodynamic stress. (2007, background): “It is involved in the turnover of mitochondria and peroxisomes and is the major lysosomal pathway for the nonselective delivery of cytoplasmic components during periods of starvation or stress (5, 7).”
A critical role for the autophagy gene Atg5 in T cell survival and proliferation (2007, neutral): “Although autophagy has been long recognized, only recently have its essential roles in various cellular functions been established (3, 4).”
FoxO3 controls autophagy in skeletal muscle in vivo. (2007, background): “Cultured mammalian cells die rapidly if autophagy is inhibited following nutrient deprivation or growth-factor withdrawal (Lum et al., 2005), and mice deficient in the Atg5 or Atg7 autophagy genes do not survive the early neonatal starvation period (Komatsu et al., 2005; Kuma et al., 2004).”
Hypoxia signalling in cancer and approaches to enforce tumour regression (2006, background): “The third step to accelerate tumour necrosis might be to suppress, in combination with other treatments, macro-autophag”
The unfolded protein response protects human tumor cells during hypoxia through regulation of the autophagy genes MAP1LC3B and ATG5. (2010, background): “During conditions of stress and starvation, cellular organelles and cytoplasmic content are degraded, thereby enabling the cells to recycle amino acids and nutrients to maintain protein synthesis and ATP generation (24, 50).”
Bcl-2 antiapoptotic proteins inhibit Beclin 1-dependent autophagy. (2005, background): “When intracellular nutrients are limited, as in the case of starvation or growth factor deprivation, autophagy genes are essential to maintain cellular ATP energy production, macromolecular synthesis, and cell survival (Lum et al., 2005).”