Bcl-2 family proteins and cancer

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Apoptosis: A Target for Anticancer Therapy (2018, background): “For instance, in almost half of all human cancers, BCL-2 expression is elevated [16].”
Role of Bcl-2 family proteins and caspases in the regulation of apoptosis (2011, background): “An imbalance among the Bcl-2 family of proteins, in favor of the anti-apoptotic members, is a phenomenon that naturally, and frequently occurs in cancer cells [201–203].”
Directed elimination of senescent cells by inhibition of BCL-W and BCL-XL (2016, neutral): “The BCL-2 protein family plays a central role in cell death regulation by diverse mechanisms, including apoptosis and autophagy 16,18,19 .”
Apoptosis and cancer: the genesis of a research field (2009, background): “The activity of these proteins is normally kept in check by controlling their expression or by post-translational modification; for a review, see Ref”