The unfolded protein response protects human tumor cells during hypoxia through regulation of the autophagy genes MAP1LC3B and ATG5.

By Kasper M A Rouschop, T. van den Beucken, L. Dubois, H. Niessen, J. Bussink, K. Savelkouls, T. Keulers, H. Mujcic, W. Landuyt, J. Voncken and 4 more. Journal of Clinical Investigation, 2010

816 citations recorded by the source corpus.

Subfields: Cell Biology, Epidemiology, Geriatrics and Gerontology

View Paper: https://www.semanticscholar.org/paper/2b95d0628fead0112ffb5cc2beb3c0e6be8a9431

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Citations in the corpus

The eIF2α/ATF4 pathway is essential for stress-induced autophagy gene expression (2013, background): “Recently, Map1lc3b and Atg5 have also been identified as targets of ATF4 and CHOP through the PERK/ eIF2a pathway (34,55).”
ER stress: Autophagy induction, inhibition and selection (2015, background): “1C).(105) Similarly, ATG12 mRNA and protein levels are also enhanced by phosphorylated EIF2S1, a downstream regulator of EIF2AK3.”
Autophagy and the integrated stress response (2010, neutral): “PERK mediates the transcriptional activation of the proteins LC3 and Atg5 in hypoxic responses through the action of the transcription factors ATF4 and CHOP, respectively (Rouschop et al., 2010).”
The C/EBP Homologous Protein (CHOP) Transcription Factor Functions in Endoplasmic Reticulum Stress-Induced Apoptosis and Microbial Infection (2019, background): “Recent studies have identified CHOP as a direct regulator of numerous genes involved in the pro-survival autophagic process (99, 100).”
Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) (2012, neutral): “In this regard, the transcriptional induction of LC3 may be necessary to replenish the LC3 protein that is turned over during extensive ER stressand hypoxia-induced autophagy.(602,608) In the clinical setting, tissue expression of ATG5, LC3A and LC3B and their respective proteins accompanies elevate”
The eIF2α kinases: their structures and functions (2013, neutral): “In addition, recent reports implicate both ATF4 and CHOP in inducing autophagy under hypoxic conditions [165, 168].”
Strategies to improve radiotherapy with targeted drugs (2011, background): “Model compounds that reduce hypoxic tolerance have shown efficacy in preclinical models, demonstrating increased ionizing radiation responses resulting from reduced hypoxic fraction”
The integrated stress response (2016, neutral): “Recent studies have connected ATF4 and CHOP with autophagy induction in mammalian cells [6,103,121].”
Guidelines for the use and interpretation of assays for monitoring autophagy (2012, background): “In this regard, the transcriptional induction of LC3 may be necessary to replenish the LC3 protein that is turned over during extensive ER stress- and hypoxia-induced autophagy.(443,448) Thus, assessing the mRNA levels of LC3 and other autophagy-related genes by northern blot or qRT-PCR may provide ”