Linking of autophagy to ubiquitin-proteasome system is important for the regulation of endoplasmic reticulum stress and cell viability.

By W. Ding, Hong-Min Ni, Wentao Gao, T. Yoshimori, D. Stolz, D. Ron, Xiao-Ming Yin. American Journal of Pathology, 2007

713 citations recorded by the source corpus.

Subfields: Cell Biology, Clinical Biochemistry, Epidemiology

View Paper: https://www.semanticscholar.org/paper/43ddf349f7e7af8ff15de9faa2a448e08207cbdb

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cell Biology

1. E. White
2. Robert S. DiPaola
3. Jennifer Lippincott-Schwartz
4. V. Karantza-Wadsworth
5. M. Cerf
6. R. Kang
7. H. J. Zeh
8. Bradly G. Wouters

In Clinical Biochemistry

1. D. Tang
2. R. Kang
3. H. J. Zeh
4. Jennifer Lippincott-Schwartz
5. M. Cerf
6. Michael Lotze
7. Xiao-Ming Yin
8. W. Ding

In Epidemiology

1. E. White
2. D. Tang
3. R. Kang
4. Robert S. DiPaola
5. R. Amaravadi
6. Jennifer Lippincott-Schwartz
7. V. Karantza-Wadsworth
8. M. Cerf

Citations in the corpus

• Beta Cell Dysfunction and Insulin Resistance (2013, background): “Autophagy is a pathway for cells to degrade organelles and is an adapted mechanism for cells to reduce ROS (Scherz-Shouval and Elazar, 2011) and eliminate ER stress (Ding et al., 2007).”
• Mitophagy: mechanisms, pathophysiological roles, and analysis (2012, background): “, 2010a), invading microbes (xenophagy) (Levine, 2005; Kudchodkar and Levine, 2009), and protein aggregates (Ding et al., 2007; Komatsu et al., 2007; Ding and Yin 2008; Matsumoto et al., 2011).”
• The unfolded protein response protects human tumor cells during hypoxia through regulation of the autophagy genes MAP1LC3B and ATG5. (2010, background): “During autophagy, the fraction of MAP1LC3B at the inner membrane of the autophagosome is subject to degradation upon fusion with a lysosome, which must be replenished to allow the cell to maintain autophagy (29, 30).”
• PAMPs and DAMPs: Signal 0s that Spur Autophagy and Immunity (2012, background): “Impairment of the UPS is compensated by upregulation of autophagy (28).”
• Role of autophagy in cancer (2007, background): “Protein turnover by lysosomal degradation through the autophagy pathway is functionally coupled to, and compensatory with, the ubiquitin-mediated proteasome protein degradation pathwa”
• Autophagy Suppresses Tumorigenesis Through Elimination of p62 (2009, positive): “Thus, autophagy maintains protein quality control cooperatively with the ubiquitin-proteasome pathway, consistent with suppression of proteasome function activating autophagy, the inhibition of which promotes cell death (Ding et al., 2007).”
• Principles and Current Strategies for Targeting Autophagy for Cancer Treatment (2011, background): “A number of studies indicate functional connections between these two degradation systems (57, 58).”