ATM and ATR Substrate Analysis Reveals Extensive Protein Networks Responsive to DNA Damage
By S. Matsuoka, Bryan A. Ballif, Agata Smogorzewska, E. McDonald, Kristen E. Hurov, Ji Luo, C. Bakalarski, Zhenming Zhao, N. Solimini, Y. Lerenthal and 3 more. Science, 2007
3,199 citations recorded by the source corpus.
Subfields: Molecular Biology, Oncology
View Paper: https://www.semanticscholar.org/paper/024ea3c5e7e5a8f2d572b501919cc82bd206d498
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In Molecular Biology
- Matthias Mann
- Jüergen Cox
- Chunaram Choudhary
- Stephen P. Jackson
- John R. Yates III
- Jesper V. Olsen
- Lars Juhl Jensen
- C. Ruse
In Oncology
- Matthias Mann
- Stephen P. Jackson
- L. Zou
- Alexandre Maréchal
- Chunaram Choudhary
- R. J. Lefkowitz
- E. Olson
- S. Polo
Citations in the corpus
- ATM Activation by Oxidative Stress (2010, background): “The crosstalk between AKT and ATM pathways was also confirmed in an effort to analyze extensive protein networks regulated by ATM and ATR [30].”
- A Directed Protein Interaction Network for Investigating Intracellular Signal Transduction (2011, background): “Inthisanalysis Inthisanalysis,wecandifferentiatebetweenfirst-orderandsecond-orderphosphorylationevents,supportingtheobservationthatsecond-site ( 32 , 33 ).”
- The DNA Damage Response: Making it safe to play with knives (2010, background): “A large number of DDR-deficient mice and various human DDR syndromes, such as A-T, BS, and FA, display aberrant meiotic progression and infertility (Table 2) (Biton et al., 2008; Bohr, 2008; Matzuk and Lamb, 2008).”
- Quantitative Phosphoproteomics Reveals Widespread Full Phosphorylation Site Occupancy During Mitosis (2010, background): “repair, another SILAC-based study of this process also identified most of these sites (6).”
- Decoding signalling networks by mass spectrometry-based proteomics (2010, positive): “For example, to affinity enrich ataxia telangiectasia mutated ( ATM ) and ataxia telangiectasia and RAD3-related ( ATR ) substrates in the DNA damage response pathway, phosphospecific-antibodies have been used that are directed against the Ser/Thr-Gln motif, which ATM and ATR phosphorylate”
- Repair Pathway Choices and Consequences at the Double-Strand Break (2015, neutral): “ATM recruits and phosphorylates all members of the MRN complex [36], which subsequently leads to ATMdependent phosphorylation of other HR components, including BRCA1 [37], CtIP, EXO1, and BLM, and promotes efficient DSB resection [38,39].”
- Regulation and Cellular Roles of Ubiquitin-specific Deubiquitinating Enzymes (2009, background): “Often, these checkpoints involve surveillance of genome integrity, and many mutations that affect cell cycle regulation and DNA repair are incompatible with the establishment of stable cell lines (23, 113, 153, 176).”
- Histone deacetylases 1 and 2 redundantly regulate cardiac morphogenesis, growth, and contractility. (2007, methodology): “2003) was performed essentially as described (Matsuoka et al. 2007).”
- Mapping Intact Protein Isoforms in Discovery Mode Using Top Down Proteomics (2011, neutral): “X was found, consistent with engagement of the DNA-repair machinery 24 .”