A Directed Protein Interaction Network for Investigating Intracellular Signal Transduction

By Arunachalam Vinayagam, Ulrich Stelzl, Raphaele Foulle, S. Plassmann, Martina Zenkner, Jan Timm, H. Assmus, Miguel Andrade, Erich E. Wanker. Science Signaling, 2011

364 citations recorded by the source corpus.

Subfields: Molecular Biology

View Paper: https://www.semanticscholar.org/paper/ef97be586ec6293350f6b1e4b17a3fd3300d13d7

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Biology

1. Roded Sharan
2. Trey Ideker
3. Lenore J. Cowen
4. Jörg Menche
5. Benjamin J. Raphael
6. Susan Dina Ghiassian
7. Albert-László Barabási
8. Ziv Bar-Joseph

Citations in the corpus

• Studying and modelling dynamic biological processes using time-series gene expression data (2012, methodology): “…and regulatory networks rely on gene knockouts 89 , genetic screen hits 90 , phosphoproteomic data 91 , or known plasma membrane-localized receptors 92 to define a set of source nodes in a protein–protein interaction network and then search for explanatory paths from these sources to the…”
• A DIseAse MOdule Detection (DIAMOnD) Algorithm Derived from a Systematic Analysis of Connectivity Patterns of Disease Proteins in the Human Interactome (2015, background): “Signaling interactions: The dataset from [50] provides 32,706 interactions between 6,339 proteins that integrate several sources, both high-throughput and literature curation, into a directed network in which cellular signals are transmitted by proteins-protein interactions.”
• Network-based in silico drug efficacy screening (2016, neutral): “…protein–protein interaction (PPI) network compiled by Menche et al. 12 that contained experimentally documented human physical interactions from TRANSFAC 38 , IntAct 39 , MINT 40 , BioGRID 41 , HPRD 42 , KEGG 43 , BIGG 44 , CORUM 45 , PhosphoSitePlus 46 and a large scale signalling network 47 .”
• Network propagation: a universal amplifier of genetic associations (2017, background): “However, the underlying network over which the propagation process is run is typically assumed to be undirected 32 , either because it models undirected relationships (such as co-complex membership) or because of missing information about edge directions (which is the case for most PPIs 33 ).”