Decoding signalling networks by mass spectrometry-based proteomics

By Chunaram Choudhary, Matthias Mann. Nature reviews. Molecular cell biology, 2010

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A Proteome-wide, Quantitative Survey of In Vivo Ubiquitylation Sites Reveals Widespread Regulatory Roles (2011, background): “Nearly all of these sites are modified by other PTMs, such as acetylation and methylation, that are known to play important roles in the regulation of chromatin-associated processes (45).”
Phenomics: the next challenge (2010, background): “, although detection of rare molecules in complex mixtures is still problemati”
PHOSIDA 2011: the posttranslational modification database (2010, unknown): “In recent years, mass spectrometry (MS)-based proteomics has proven a powerful and generic tool to study these events on a global scale (3).”
Ultradeep human phosphoproteome reveals a distinct regulatory nature of Tyr and Ser/Thr-based signaling. (2014, methodology): “…mass spectrometry (MS) has proved to be Cell Re an ideal platform because it is a highly precise yet generic method for the global identification and quantification of proteins and their modifications (Choudhary and Mann, 2010; Hein et al., 2013; Junger and Aebersold, 2013; Lemeer and Heck, 2009).”
Inaugural Article: The protein expression landscape of the Arabidopsis root (2012, unknown): “Proteome maps are useful representations of the complex “building plan” of a biological system and also serve as valuable tools for the discovery of new cellular functions (2, 3).”