Toll-like receptor 7 and TLR9 dictate autoantibody specificity and have opposing inflammatory and regulatory roles in a murine model of lupus.
By S. Christensen, J. Shupe, K. Nickerson, M. Kashgarian, R. Flavell, M. Shlomchik. Immunity, 2006
1,112 citations recorded by the source corpus.
Subfields: Immunology, Rheumatology
View Paper: https://www.semanticscholar.org/paper/bbf104d8f0d3218c9d5e87cf656af5675cb91028
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
In Immunology
- Shizuo Akira
- R. Medzhitov
- Daniel B. Stetson
- O. Takeuchi
- Yong‐jun Liu
- Taro Kawai
- F. Barrat
- M. Gilliet
In Rheumatology
Citations in the corpus
- Plasmacytoid dendritic cells: sensing nucleic acids in viral infection and autoimmune diseases (2008, background): “Accordingly, TLR7-deficient lupus-prone mice have ameliorated autoimmune diseases with decreased lymphocyte activation and serum autoantibodies, as well as reduced severity of nephriti”
- Emerging Role of Endosomal Toll-Like Receptors in Rheumatoid Arthritis (2013, background): “An immunoregulatory role was attributed to TLR9 following knockout, despite its requirement for pathogenic anti-DNA autoantibody production (48).”
- Self-RNA–antimicrobial peptide complexes activate human dendritic cells through TLR7 and TLR8 (2009, background): “…demonstrated in mouse models of SLE using TLR7- or TLR9-deficient mice or inhibitors for TLR7 and TLR9 (Leadbetter et al., 2002; Lau et al., 2005; Christensen et al., 2006; Barrat et al., 2007), and by a study showing that TLR7 gene duplication in mice induces SLE-like disease (Deane et al.,…”
- Trex1 prevents cell-intrinsic initiation of autoimmunity (2008, positive): “TLR7 and TLR9 are important for autoantibody production in a murine model of lupus (Christensen et al., 2006), and a spontaneous gene duplication of murine TLR7 predisposes to autoimmunity (Pisitkun et al., 2006; Subramanian et al., 2006).”
- Pattern recognition receptors and inflammation. (2010, background): “Reciprocally, TLR7 deficiency in lupus-prone MRL lpr/lpr mice results in reduced levels of autoantibodies recognizing RNA-containing antigens and abrogation of disease (Christensen et al., 2006).”