Serum response factor regulates a muscle-specific microRNA that targets Hand2 during cardiogenesis

By Yong Zhao, Eva Samal, Deepak Srivastava. Nature, 2005

1,678 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/01fc00ceeaed3297639d91a0ce3d478d49273b76

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Citations in the corpus

Long noncoding RNAs in mouse embryonic stem cell pluripotency and differentiation. (2008, neutral): “2006), and embryogenesis (Wienholds et al. 2005; Zhao et al. 2005; Mineno et al. 2006).”
Role of microRNAs in vascular diseases, inflammation, and angiogenesis. (2008, background): “There is an increasing evidence that specific miRNAs are involved in various biological processes such as cardiogenesis, skeletal muscle proliferation and differentiation, brain morphogenesis, oncogenesis, and haematopoietic lineage differentiation.(12,13,25,32,33) While the function of Dicer and Dr”
miRecords: an integrated resource for microRNA–target interactions (2008, background): “The summary of a target gene level, exogenous miRNA experiment includes D ow nloaded from https://academ ic.oup.com /nar/article-abstract/37/suppl_1/D 105/1015895 by guest on 15 M arch 2020 the method of manipulating the miRNA level (e.g. ‘overexpression by mature miRNA transfection’, or ‘underexpre”
Animal MicroRNAs confer robustness to gene expression and have a significant impact on 3'UTR evolution. (2005, positive): “This indicates that these two miRNAs are conserved not only in sequence and spatial expression from flies to vertebrates but also in their tendency to avoid coexpressed genes (Lim et al., 2005; Wienholds et al., 2005; Zhao et al., 2005; Sokol and Ambros, 2005).”
MicroRNA function: multiple mechanisms for a tiny RNA? (2005, background): “1753 cific expression of miR-1 (Zhao et al. 2005) and Myc in regulating a specific miRNA cluster (O’Donnell et al. 2005) was recently demonstrated.”
MEF2: a central regulator of diverse developmental programs (2007, background): “…an additional level of myogenic regulation by regulating the expression of microRNAs (miRs), such as miR-1 and miR-133 (Sokol and Ambros, 2005; Zhao et al., 2005), that posttranscriptionally repress gene expression by binding the 3 untranslated regions of mRNA targets and disrupting mRNA…”
microPrimer: the biogenesis and function of microRNA (2005, methodology): “…2005), and also miR-1, a mouse miRNA whose expression is confined to cardiac and skeletal muscle precursor cells, and which may control the balance between differentiation and proliferation during cardiogenesis by regulating the expression of Hand2 mRNA (Wienholds et al., 2005; Zhao et al., 2005).”
A Long Noncoding RNA Controls Muscle Differentiation by Functioning as a Competing Endogenous RNA (2011, positive): “Moreover, recent studies have shown that these myogenic transcription factors not only control protein-coding genes but also regulate the expression of specific miRNAs (Zhao et al., 2005; Rao et al., 2006).”
Targeted deletion of Dicer in the heart leads to dilated cardiomyopathy and heart failure (2008, background): “It is intriguing that a single miRNA (miR-1) appears to be involved in the regulation of diverse cardiac and skeletal muscle function, including cellular proliferation, differentiation, cardiomyocyte hypertrophy, cardiac conduction, and arrhythmias (8, 10, 11, 26, 30).”
TransmiR: a transcription factor–microRNA regulation database (2009, background): “This binding results in cleavage or translation inhibition of the target mRNAs (1–3). miRNAs play critical roles in many essential biological processes, such as proliferation (4,5), metabolism (6,7), diﬀerentiation (8), development (9,10), apoptosis (7,11,12) and cellular signaling (13).”
Transactivation of miR-34a by p53 broadly influences gene expression and promotes apoptosis. (2007, background): “For instance, a number of well-studied mammalian transcription factors including c-Myc, cAMP-response element binding protein (CREB), and MyoD have been shown to control both mRNA and miRNA expression (O’Donnell et al., 2005;Rao et al., 2006;Vo et al., 2005;Zhao et al., 2005).”
A mutation creating a potential illegitimate microRNA target site in the myostatin gene affects muscularity in sheep (2006, background): “Notably, miR-1 has previously been shown to be strongly expressed in skeletal muscle and heart in the mous”
MicroRNA-133 controls cardiac hypertrophy (2007, background): “24 and data not shown), whereas it has been suggested that serum response factor (SRF) regulates miR-1 expression in transgenic mic”
MicroRNA functions in animal development and human disease (2005, background): “An analysis of the upstream-regulatory sequence of these two genes has led to the identification of serum response factor (Srf), myocardin, Mef2 and Myod as transcriptional regulators of miR-1 expression in vitro (Zhao et al., 2005).”