MicroRNA functions in animal development and human disease

By Inés Álvarez-García, E. Miska. Development, 2005

1,345 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/35bd04b282fba2dcf28c3dc9e7eb1708782b7fc9

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Citations in the corpus

Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells (2007, background): “In addition, the exosomal miRNAs miR-1, miR-17, miR-18, miR-181 and miR-375 have been suggested to have roles in angiogenesis, haematopoiesis, exocytosis and tumorogenesi”
Controlling morpholino experiments: don't stop making antisense (2008, background): “…of that protein. microRNA-blocking MOs MicroRNAs are short (about 22 nucleotides), non-coding RNA molecules that regulate gene expression by both blocking the translation and promoting the decay of their target mRNAs (Alvarez-Garcia and Miska, 2005; Bushati and Cohen, 2007; Farazi et al., 2008).”
microRNAs as oncogenes and tumor suppressors. (2007, background): “, 2005), disease (Abelson et al., 2005; Alvarez-Garcia and Miska, 2005), and cancer (Meltzer, 2005; Volinia et al.”
The microRNA miR-124 antagonizes the anti-neural REST/SCP1 pathway during embryonic CNS development. (2007, background): “Indeed, miRNAs have been implicated in many biological processes (Carrington and Ambros 2003; Ambros 2004; Alvarez-Garcia and Miska 2005).”
The muscle-specific microRNA miR-1 regulates cardiac arrhythmogenic potential by targeting GJA1 and KCNJ2 (2011, background): “dtd" [ ]> MicroRNAs (miRNAs) are endogenous noncoding RNAs, about 22 nucleotides in length, that mediate post-transcriptional gene silencing by annealing to inexactly complementary sequences in the 3′-untranslated regions of target mRNA”
Expression profiling identifies microRNA signature in pancreatic cancer (2006, background): “While the biological roles of miRNA are under intense investigation, they are believed to define and maintain cellular fate in a manner similar to transcription factors(40) by regulating developmental timing and differentiation.(41) Since alterations in developmental pathways play a critical role in”
Animal MicroRNAs confer robustness to gene expression and have a significant impact on 3'UTR evolution. (2005, positive): “Their importance is evidenced by evolutionary conservation andbythemanybiologicalprocessesinwhichthey are implicated, including developmental timing, cell proliferation,apoptosis,metabolism,celldifferentiation,andmorphogenesis ( Alvarez-Garcia and Miska, 2005; Ambros, 2004).”
MicroRNA expression profiling of human breast cancer identifies new markers of tumor subtype (2007, background): “However, studies in roundworms, flies, fish and mice have demonstrated important roles for miRNAs in animal development [37].”