Targeted deletion of Dicer in the heart leads to dilated cardiomyopathy and heart failure

By Jian-Fu Chen, E. Murchison, Ruhang Tang, T. Callis, M. Tatsuguchi, Zhongliang Deng, M. Rojas, Scott M. Hammond, M. Schneider, C. Selzman and 4 more. Proceedings of the National Academy of Sciences of the United States of America, 2008

602 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/0850d7e252d6a0a85ac755ae33cc13341005a102

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In Cancer Research

1. E. Olson
2. E. Small
3. Maria-Teresa Piccoli
4. Ruben Garcia-Martin
5. R. Kahn
6. J. Beermann
7. M. Clarke
8. R. G. Ludwig

In Molecular Biology

1. E. Olson
2. E. Small
3. Piero Dalerba
4. Dalong Qian
5. Y. Shimono
6. N. Lobo
7. Robert W. Cho
8. Maria-Teresa Piccoli

Citations in the corpus

• Extracellular miRNAs: From Biomarkers to Mediators of Physiology and Disease (2019, background): “DICER knockout in the central nervous system, pancreas, or skeletal and cardiac muscles renders mice nonviable or with severe developmental defects (Chen et al., 2008; Kawase-Koga et al., 2009; Lynn et al., 2007; O’Rourke et al., 2007).”
• Pathophysiology of cardiac hypertrophy and heart failure: signaling pathways and novel therapeutic targets (2015, background): “Mice with cardiac deletion of Dicer, the enzyme involved in miRNA processing, developed HF and died 4 days after birth (Chen et al. 2008).”
• microRNA-1 and microRNA-206 regulate skeletal muscle satellite cell proliferation and differentiation by repressing Pax7 (2010, positive): “Mice, satellite cell isolations, and cell cultures Mice carrying the Dicer floxed allele (Dicer flox/flox ) were described previously (Murchison et al., 2005; Chen et al., 2008).”
• MicroRNA-208a is a regulator of cardiac hypertrophy and conduction in mice. (2009, background): “The global role of miRNA function in the heart has been addressed by conditionally inhibiting miRNA maturation in the murine heart and has revealed that miRNAs play an essential role during development (13, 14).”
• Down-regulation of miRNA-200c Links Breast Cancer Stem Cells with Normal Stem Cells (2009, background): “In addition, tissue-specific deletion of Dicer affects selfrenewal of embryonic stem cells, development of B lymphocyte lineage cells, and tissue morphogenesis (Chen et al., 2008; Davis et al., 2008; Koralov et al., 2008).”
• Non-coding RNAs in Development and Disease: Background, Mechanisms, and Therapeutic Approaches. (2016, background): “In the heart, conditional knockout of Dicer leads to progressive dilated cardiomyopathy and heart failure (44) as well as congenital cardiovascular abnormalities (239).”
• Molecular mechanisms of diabetic cardiomyopathy (2014, neutral): “Global dysregulation of the miRNA biogenesis machinery in the heart by cardiomyocyte-specific deletion of dicer leads to rapidly progressive dilated cardiomyopathy and heart failure [127].”
• Pervasive roles of microRNAs in cardiovascular biology (2011, positive): “Lethal phenotypes were observed after Dicer deletion in myocardial and vascular lineage”