Animal MicroRNAs confer robustness to gene expression and have a significant impact on 3'UTR evolution.

By Alexander Stark, J. Brennecke, Natascha Bushati, Robert B. Russell, Stephen M Cohen. Cell, 2005

1,187 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/7c8f692dbace01ac0769a4a784413d048a6cf4a6

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cancer Research

In Molecular Biology

Citations in the corpus

Recognizing and avoiding siRNA off-target effects for target identification and therapeutic application (2010, neutral): “This is reminiscent of the targets of mammalian microRNA”
Metazoan MicroRNAs (2018, neutral): “…ones (Agarwal et al., 2015; Denzler et al., 2016). miRNA Target Abundance By virtue of their small size, seed-matched regulatory sites can readily emerge in 3′ UTRs, enabling each miRNA to have a widespread influence on mRNA regulation and 3′ UTR evolution (Farh et al., 2005; Stark et al., 2005).”
Evolution of microRNA diversity and regulation in animals (2011, neutral): “Analyses of expression patterns of miRNAs and their predicted target genes have revealed two distinct trends in the expression of conserved and non-conserved targets relative to their cognate miRNA”
Biological principles of microRNA-mediated regulation: shared themes amid diversity (2008, neutral): “It was also suggested that many genes would be negatively affected by the acquisition of miRNA-binding sites, and 'anti-targets' that are depleted for miRNA-binding sites indeed exis”
A guide through present computational approaches for the identification of mammalian microRNA targets (2006, neutral): “For this reason it is also necessary to calculate the specificity, or the 'false positive rate”
A mammalian microRNA expression atlas based on small RNA library sequencing. (2007, neutral): “Other mRNAs appear to be under selective pressure to avoid complementarity to coexpressed highly abundant miRNAs (Farh et al., 2005; Stark et al., 2005; Sood et al., 2006).”
Functions of microRNAs and related small RNAs in plants (2006, neutral): “and to have at some point influenced the expression of nearly the entire genom”
Specialization and evolution of endogenous small RNA pathways (2007, neutral): “melanogaster and human genes indicates that genes that are coexpressed with miRNAs avoid evolving target seeds for those miRNA”
Transcriptome-wide identification of RNA-binding protein and microRNA target sites by PAR-CLIP (2010, neutral): “Highly expressed mRNAs appear to avoid miRNA regulation (Stark et al., 2005), at least for those miRNAs expressed in HEK293 cells.”
microRNAs as oncogenes and tumor suppressors. (2007, positive): “…in direct cleavage of the targeted mRNAs or inhibiting translation through perfect or nearly perfect complementarity to targeted mRNAs at the 3′ untranslated regions (UTRs) of the targets in animals (de Moor et al., 2005; Lai, 2002; Robins and Press, 2005; Stark et al., 2005; Sun et al., 2005).”
The evolution of gene regulation by transcription factors and microRNAs (2007, neutral): “Indeed, the existence of many genes for which the presence of a miRNA binding site would be deleterious ('anti-targets') was proposed [93] and later demonstrated by several groups in various species using microarray data and computational studies [72,73,89,94, 95 ].”