Transactivation of miR-34a by p53 broadly influences gene expression and promotes apoptosis.

By Tsung-Cheng Chang, Erik A. Wentzel, O. Kent, Kalyani Ramachandran, M. Mullendore, K. Lee, G. Feldmann, M. Yamakuchi, M. Ferlito, C. Lowenstein and 4 more. Molecules and Cells, 2007

2,104 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/992f2384d2ee7fd7b3a759452eb41a4a41de8e51

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Citations in the corpus

Widespread microRNA repression by Myc contributes to tumorigenesis (2008, methodology): “For three of the transcripts, spliced ESTs were available to use as a starting point for RACE; in addition, we previously reported the complete structure of the primary transcript of miR-34a (ref”
MicroRNAs in development and disease. (2011, background): “Notably, transcription of the miR34a gene is also dependent on p53 and is accordingly depressed in cancer cells lacking p53 (85, 118, 239, 503, 599).”
Epigenetic silencing of microRNA-34b/c and B-cell translocation gene 4 is associated with CpG island methylation in colorectal cancer. (2008, background): “On the other hand, Chang and colleagues, who also performed a microarray analysis of HCT116 cells with forced miR-34a expression, found that the most highly enriched category among up-regulated genes was cell cycle genes (30).”
MicroRNAs in human cancer. (2013, background): “Examples include the TP53 regulated mir-34a [57, 58], the RAS regulated mir-21 [33, 59, 60] and the MYC regulated mir-17-92 gene cluster [61, 62].”
The mammalian ovary from genesis to revelation. (2009, background): “Aside from ovarian cancer, reduced mir-34 expression has been reported in neuroblastoma (658), pancreatic cancer (653), and non-small cell lung cancer (652).”
MicroRNAs — the micro steering wheel of tumour metastases (2009, neutral): “pl?acc=MI0000268"> miR-34a is positively controlled by p53 (Ref”
MicroRNA and cancer (2012, background): “In accordance with a tumour-suppressive role, miR-34 members are downregulated in various cancers and the miR-34a locus located at 1q36 has been found lost in cases of neuroblastomas and in pancreatic cancer cell lines (Chang et al., 2007; Welch et al., 2007).”
Blinded by the Light: The Growing Complexity of p53. (2009, background): “Satisfyingly, some of the aforementioned studies uncovering p53 regulation of the miRNA locus report markedly lower amounts of miR-34 in some human tumors and tumor-derived cell lines (Bommer et al., 2007; Chang et al., 2007; Tazawa et al., 2007).”
MicroRNAs in stress signaling and human disease (2012, background): “…the miR-34a and miR-34b/miR-34c transcription units which then are able to mediate some aspects of the cellular response to p53 activation, including cell-cycle arrest and apoptosis (Bommer et al., 2007; Chang et al., 2007; He et al., 2007; Raver-Shapira et al., 2007; Tarasov et al., 2007).”
ChIPBase: a database for decoding the transcriptional regulation of long non-coding RNA and microRNA genes from ChIP-Seq data (2012, background): “Moreover, the distances between transcription initiation sites (TSSs) and miRNA genes dramatically vary, ranging from a hundred bases to thousands of bases upstream (33,34).”
The role of let-7 in cell differentiation and cancer. (2010, background): “expression, which in turn leads to cell cycle arrest and apoptosis induction (Chang et al. 2007).”
OncomiRs: the discovery and progress of microRNAs in cancers (2007, background): “It was likely that an important function of miR-34a was the modulation and finetuning of the gene expression program initiated by p53 [37].”