A mutation creating a potential illegitimate microRNA target site in the myostatin gene affects muscularity in sheep

By A. Clop, Fabienne Marcq, H. Takeda, Dimitri Pirottin, X. Tordoir, B. Bibé, J. Bouix, F. Caiment, J. Elsen, F. Eychenne and 7 more. Nature Genetics, 2006

1,298 citations recorded by the source corpus.

Subfields: Molecular Biology

View Paper: https://www.semanticscholar.org/paper/d3db169d6945ec24c515a6d4b4df71269d118cbe

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Biology

Citations in the corpus

The Genetic Signatures of Noncoding RNAs (2009, background): “As noted above, regulatory mutations have been identified in the 39 UTRs of mRNAs, such as those underlying Tourette’s syndrome [115] and muscular hypertrophy in sheep [116], which appear to involve gain- or loss-of-function of miRNA binding sites.”
Small non-coding RNAs in animal development (2008, background): “A recent study has identified a G→A transition in the 3′ UTR of a myostatin gene that negatively regulates muscle mass in these shee”
Non-coding RNAs in human disease (2011, background): “Finally, SNPs that affect miRNA-binding sites, including those for miR-1, have been associated with unrestricted muscular growt”
Cellular and molecular mechanisms of muscle atrophy (2013, background): “Mutations of the myostatin gene lead to a hypertrophic phenotype in mice, sheep and cattle, and a lossof-function mutation in the human myostatin gene was also found to induce increased muscle mass (Clop et al., 2006; Lee and McPherron, 2001; McPherron and Lee, 1997; Schuelke et al., 2004).”
The neuronal microRNA system (2006, background): “The most clear-cut case of a disease caused by a specific miRNA is the G to A transition in the 3′ UTR of the myostatin/growth differentiation factor 8 gene in Texel sheep, which are famous for their high-quality mea”
Evolution of microRNA diversity and regulation in animals (2011, background): “A prominent example of the phenotypic consequences of target site polymorphism is the muscular hypertrophy that is seen in Texel sheep owing to creation of a target site for miR-1 and miR-126 by a G-to-A transition in the 3′UTR of the myostatin gen”
Pervasive roles of microRNAs in cardiovascular biology (2011, background): “A notable example is in the Texel breed of sheep, which develops extreme skeletal muscle hypertrophy owing to an SNP in the 3′ UTR of the mRNA encoding myostatin, a negative regulator of muscle growt”
MicroRNAs in stress signaling and human disease (2012, background): “This concept was initially validated through analysis of quantitative trait loci that influence muscle mass in sheep (Clop et al., 2006).”
A Mutation in the Myostatin Gene Increases Muscle Mass and Enhances Racing Performance in Heterozygote Dogs (2007, background): “Double muscling has been described in several breeds of cattle [5,6,15–17] and muscular hypertrophy (an increase in muscle-fiber size) has been described in sheep [7].”