Active genes are tri-methylated at K4 of histone H3

By H. Santos‐Rosa, Robert Schneider, Andrew J. Bannister, Julia A. Sherriff, Bradley E. Bernstein, N. Emre, Stefan Schreiber, J. Mellor, Tony Kouzarides. Nature, 2002

2,252 citations recorded by the source corpus.

Subfields: Molecular Biology

View Paper: https://www.semanticscholar.org/paper/016080fee7e476cf93cab155fddb374b2634794b

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Citations in the corpus

The histone modification pattern of active genes revealed through genome-wide chromatin analysis of a higher eukaryote. (2004, result): “This observation contrasts with studies in budding yeast, which suggested that Lys 4 dimethylation marks active and activatable genes, whereas Lys 4 trimethylation is an exclusive mark for highly expressed genes (Santos-Rosa et al. 2002; Ng et al. 2003b).”
The X-linked mental retardation gene SMCX/JARID1C defines a family of histone H3 lysine 4 demethylases. (2007, positive): “Histone H3K4 trimethylation positively regulates transcription (Liang et al., 2004; Litt et al., 2001; Noma et al., 2001; Santos-Rosa et al., 2002; Schneider et al., 2004) in part by recruiting chromatin-remodeling complexes (Santos-Rosa et al.”
A chromatin landmark and transcription initiation at most promoters in human cells. (2007, background): “Previous studies have emphasized that nucleosomes with histone H3K4me3 are associated with actively transcribed genes in various eukaryotes (Bernstein et al., 2002; Santos-Rosa et al., 2002; Ng et al., 2003; Schneider et al., 2004; Schubeler et al., 2004; Pokholok et al., 2005).”
Physical association and coordinate function of the H3 K4 methyltransferase MLL1 and the H4 K16 acetyltransferase MOF. (2005, background): “H C T The MLL1-WDR5 Complex Is Enzymatically Active Although lysine residues may be mono-, di-, or trimeth- s a ylated in vivo, the trimethyl H3 K4 is preferentially and strongly associated with the transcribed regions of l H active genes from yeast to higher eukaryotes (Krogan et al., 2002; Ng et a”
Histone H3 lysine 4 methylation patterns in higher eukaryotic genes (2004, background): “Tri-methyl K4/H3 is a mark associated with active genes in yeast but the function of di-methyl K4/H3 is less clea”
The profile of repeat‐associated histone lysine methylation states in the mouse epigenome (2005, methodology): “…on defined chromosomal loci (Litt et al, 2001; Noma et al, 2001), parts of entire chromosomes (Greil et al, 2003; Lippman et al, 2004) and with genome-wide but promoter-biased or EST sequences that were displayed on microarrays (Ren et al, 2002; Santos-Rosa et al, 2002; Schübeler et al, 2004).”
An epigenetic road map for histone lysine methylation (2003, background): “Fully activated promoters appear to be enriched in tri-methylated H3-K4 (Santos-Rosa et al., 2002); basal transcription correlates with H3-K4 dimethylation, although the methylation potential of the HMTases involved needs to be defined (Briggs et al., 2001; Nishioka et al., 2002a; Wang et al., 2001a”
Histone and chromatin cross-talk. (2003, background): “For example, it was recently shown that dimethylation of H3-K4 occurs at both inactive and active euchromatic genes, whereas tri-methylation is present exclusively at active genes [25 ].”
The interplay between the glucocorticoid receptor and nuclear factor-kappaB or activator protein-1: molecular mechanisms for gene repression. (2003, background): “Besides acetylation, other posttranslational modifications such as phosphorylation and methylation also do occur in core histone tails (465, 466, 469, 470, 475).”