The X-linked mental retardation gene SMCX/JARID1C defines a family of histone H3 lysine 4 demethylases.

By Shigeki Iwase, F. Lan, P. Bayliss, Luis de la Torre-Ubieta, Maite Huarte, H. Qi, J. Whetstine, A. Bonni, T. Roberts, Yang Shi. Cell, 2007

702 citations recorded by the source corpus.

Subfields: Genetics, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/9a239eb03ff7c2c8dd71c7467e8e04b5818e7154

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Genetics

In Molecular Biology

Citations in the corpus

Covalent modifications of histones during development and disease pathogenesis (2007, background): “melanogaster Lid only demethylates H3K4me3 (trimethylated H3K4) to H3K4me2 in vivo , although its mammalian homologs can also convert H3K4me2 to H3K4me1 (refs”
Overexpression of the JmjC histone demethylase KDM5B in human carcinogenesis: involvement in the proliferation of cancer cells through the E2F/RB pathway (2010, background): “All four members of the JARID family possess the H3K4 demethylase activity [16-20].”
A temporarily distinct subpopulation of slow-cycling melanoma cells is required for continuous tumor growth (2010, background): “Error bars represent the SD. and normal stem cell biology (Christensen et al., 2007; Iwase et al., 2007; Klose et al., 2007; Yamane et al., 2007).”
A chromatin-mediated reversible drug tolerant state in cancer cell subpopulations (2010, background): “KDM5A was initially discovered as a retinoblastoma-binding protein (Defeo-Jones et al., 1991; Fattaey et al., 1993) and was found to exhibit histone H3K4-demethylating activity (Christensen et al., 2007; Iwase et al., 2007; Klose et al., 2007; Secombe et al., 2007).”
A Functional Link between the Histone Demethylase PHF8 and the Transcription Factor ZNF711 in X-Linked Mental Retardation (2010, unknown): “For the latter, two of the XLMR proteins, JARID1C and PHF8 (Iwase et al., 2007; Jensen et al., 2005; Laumonnier et al., 2005; Tahiliani et al., 2007), belong to the JmjC group of proteins.”
Erasing the methyl mark: histone demethylases at the center of cellular differentiation and disease. (2008, background): “The JARID1 subfamily of JmjC proteins encompasses four members: JARID1A, JARID1B, JARID1C, and JARID1D (also called KDM5A-D according to the novel nomenclature), which all can demethylate tri- and dimethylated H3K4 (Christensen et al. 2007; Iwase et al. 2007; Klose et al. 2007; Lee et al. 2007a; Tah”
Recognition of trimethylated histone H3 lysine 4 facilitates the recruitment of transcription postinitiation factors and pre-mRNA splicing. (2007, background): “More recently, enzymes that counteract the effects of H3K4me through demethylation have been found associated with various disease states (Iwase et al., 2007; Tahiliani et al., 2007).”