An epigenetic road map for histone lysine methylation

By M. Lachner, Roderick J. O’Sullivan, T. Jenuwein. Journal of Cell Science, 2003

684 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/d6cad3c4be7aca07986503b56f557bab94ec7c38

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Biology

Citations in the corpus

Elongation by RNA polymerase II: the short and long of it. (2004, background): “Silent or repressed regions co-map with methylation at the following histone lysine residues, H3-K9, H3-K27, and H4-K20, and transcriptionally active domains are typically associated with methylation at H3K4, H3-K36, and H3-K79 (Lachner et al. 2003; Sims et al. 2003).”
Histone demethylation by a family of JmjC domain-containing proteins (2006, background): “One such modiﬁcation, methylation, occurs on both lysine and arginine residues and participates in a diverse range of biological processes including heterochromatin formation, X-chromosome inactivation and transcriptional regulation 2–4 .”
The nucleosome: from genomic organization to genomic regulation. (2004, background): “Additional contacts by the bromodomain to adjacent inheritance (for review, see Lachner et al., 2003).”
The functions of E(Z)/EZH2-mediated methylation of lysine 27 in histone H3. (2004, background): “Since the initial demonstration that the SET domain is required for the HMTase activity of SUV39H1 [22], several SET domain HMTases have been identiﬁed [3,5].”
MLL translocations, histone modifications and leukaemia stem-cell development (2007, background): “As studies have linked the methylation of H3K79 to positive transcriptional regulatio”
JHDM2A, a JmjC-containing H3K9 demethylase, facilitates transcription activation by androgen receptor. (2006, background): “Histone methylation occurs on both arginine and lysine residues and is catalyzed by three different protein families which include: the protein arginine methyltransferase family, the SET domain-containing family, and the Dot1 protein family (Lachner et al., 2003; Zhang and Rein-berg, 2001).”
Learning the human chromatin network from all ENCODE ChIP-seq data (2015, background): “H3K9me3 marks constitutive heterochromatin, and acts as a more permanent repressor [32].”
Chromatin decondensation and nuclear reorganization of the HoxB locus upon induction of transcription. (2004, background): “Transcriptionally active genes are generally characterized by high levels of histone acetylation and metH3-K4 (for review, see Zhang and Reinberg 2001; Lachner et al. 2003).”
A silencing pathway to induce H3-K9 and H4-K20 trimethylation at constitutive heterochromatin. (2004, background): “Chromatin is the physiological template of the genetic information and is composed of the DNA polymer, histones, and other chromosomal proteins.”